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Next-generation metabolic engineering of non-conventional microbial cell factories for carboxylic acid platform chemicals. | LitMetric

Next-generation metabolic engineering of non-conventional microbial cell factories for carboxylic acid platform chemicals.

Biotechnol Adv

State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Industrial Fermentation Microbiology of the Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, Tianjin Engineering Research Center of Microbial Metabolism and Fermentation Process Control, College of Biotechnology, Tianjin University of Science and Technology, No.29 the 13th Street TEDA, Tianjin 300457, PR China. Electronic address:

Published: November 2020

AI Article Synopsis

  • * Recent advances in metabolic engineering of microbes offer a sustainable alternative for producing these acids, aiming to make industrial processes more eco-friendly and competitive.
  • * This review focuses on using non-conventional microbes, in addition to traditional ones like E. coli and Saccharomyces cerevisiae, for metabolically engineering production pathways to create essential carboxylic acid chemicals.

Article Abstract

Carboxylic acids contain carboxyl groups that can undergo a wide range of chemical transformation. Therefore, they serve as key platform chemicals for the production of high value-added industrial products. Currently, the majority of carboxylic acid platform chemicals is produced predominantly through traditional chemical synthesis. However, these chemical conversion processes are heavily dependent on fossil fuels and often lead to serious environmental pollution. Recently, the rapid development in metabolic engineering of microbes provide a new and promising alternative route for producing carboxylic acids as platform chemicals. We envision that these bio-based manufacturing processes using microbial cell factories will help move the industrial production of carboxylic acid platform chemicals towards a more sustainable, environmentally friendly and economically competitive direction. While Escherichia coli and Saccharomyces cerevisiae have been the workhorses for biochemical production through metabolic engineering, non-conventional microbes are emerging as suitable hosts for producing carboxylic acids to meet the needs of the industries. Here, we review the employment of metabolic engineering strategies on non-conventional microbes to serve as microbial cell factories for the production of industrially important carboxylic acid platform chemicals.

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Source
http://dx.doi.org/10.1016/j.biotechadv.2020.107605DOI Listing

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