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Chronic administration of ivabradine improves cardiac Ca handling and function in a rat model of Duchenne muscular dystrophy.
Sci Rep
March 2025
Ludwig Boltzmann Institute for Cardiovascular Research at the Center for Biomedical Research and Translational Surgery, Medical University of Vienna, 1090, Vienna, Austria.
Duchenne muscular dystrophy (DMD), a severe muscle disease caused by mutations in the gene encoding for the intracellular protein dystrophin, is associated with impaired cardiac function and arrhythmias. A causative factor for complications in the dystrophic heart is abnormal calcium (Ca) handling in ventricular cardiomyocytes, and restoration of normal Ca homeostasis has emerged as therapeutic strategy. Here, we used a rodent model of DMD, the dystrophin-deficient DMD rat, to test the following hypothesis: chronic administration of ivabradine (IVA), a drug clinically approved for the treatment of heart failure, improves Ca handling in dystrophic ventricular cardiomyocytes and thereby enhances contractile performance in the dystrophic heart.
View Article and Find Full Text PDFA green sulfidated micro zero-valent iron based-hydrogel for the synergistic removal of heavy metal cations and anions in groundwater.
Sci Total Environ
March 2025
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China; Quanzhou Institute for Environment Protection lndustry, Nanjing University, Quanzhou 362000, China; Joint International Research Centre for Critical Zone Science-University of Leeds and Nanjing University, Nanjing University, Nanjing 210023, China. Electronic address:
Heavy metal cations and anions contaminated groundwater was a big challenge to water resource safety. Herein, a green sulfidated micro zero-valent iron-based hydrogel (SA-S-mZVI) was synthesized using sodium alginate biomass for the simultaneous removal of heavy metal cations (Cu(II), Pb(II), Cd(II)) and anions (Cr(VI)). The sulfur modification and incorporation of sodium alginate hydrogel facilitated the efficient and sustainable removal of both single and multi-heavy metals.
View Article and Find Full Text PDFTire-based microplastics: Composition, detection, and impacts of advanced oxidation processes in drinking water treatment.
Sci Total Environ
March 2025
Department of Civil and Environmental Engineering, Tokyo Metropolitan University, Japan.
Microplastic pollution, particularly that from tire, presents critical environmental and public health concerns. They contribute 60 % of the total microplastic pollution. Tire-based microplastics, which contain synthetic polymers and toxic chemical additives, are significant contributors to microplastic pollution in aquatic systems.
View Article and Find Full Text PDFBioremediation of multiple heavy metals through biostimulation of microbial-induced calcite precipitation at varying calcium-to-urea concentrations.
J Hazard Mater
February 2025
Division of Infrastructure and Environment, James Watt School of Engineering, the University of Glasgow, United Kingdom. Electronic address:
Studies on heavy metal bioremediation through microbial-induced calcite precipitation (MICP) typically involve bioaugmentation approaches that use low calcium-to-urea ratios and target single contaminants. We present an investigation on the efficiency of soils' autochthonous ureolytic bacteria to simultaneously remediate multiple heavy metals and sequester carbon through urea hydrolysis and MICP on an urban soil containing excess Pb, Zn, Mn, Sr, Ba and Al. Soils were treated at a fixed urea concentration of 333 mM and increasing calcium content of 0, 50 and 333 mM to provide a range of carbonation potential.
View Article and Find Full Text PDFCoupling metal concentrations and drift simulations for tracing emissions from offshore wind farms.
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March 2025
Helmholtz-Zentrum Hereon, Institute of Coastal Environmental Chemistry, Department Inorganic Environmental Chemistry, Max-Planck Str. 1, 21502 Geesthacht, Germany. Electronic address:
During the last decade offshore wind energy production has become an important source of renewable energy. To ensure safe operation during the lifetime of an offshore wind turbine, the steel structures need to be protected against corrosion. This work evaluates potential metal emissions and environmental impacts from galvanic anodes used for corrosion protection of offshore wind farms (OWFs) by applying a novel multi-tracer approach.
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