Problems of subgroup analysis in randomized controlled trial.

BMC Anesthesiol

Department of Anesthesiology and Critical Care, Medical Center University of Freiburg, Hugstetter Straße 55, 79095, Freiburg, Germany.

Published: August 2020

Multiple subgroup analyses of the same data increase the risk of generating false positive findings. All outcomes and planned subgroup analyses should thus be prespecified and described in the original trial registry. When outcome changes during an ongoing trial seem justifiable, publications must disclose and explain such changes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7395332PMC
http://dx.doi.org/10.1186/s12871-020-01105-8DOI Listing

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