AI Article Synopsis
- The outbreak of SARS-CoV-2 in December 2019 has led to a global pandemic, highlighting the importance of studying the ACE2 receptor, which is used by the virus to enter host cells.
- A comprehensive analysis of ACE2 conservation across 1,671 eukaryotic species has revealed interesting conservation patterns and the co-evolution of proteins related to ACE2.
- The research identified existing drugs, including commonly used anti-inflammatory and vasodilator medications, that could potentially interfere with the ACE2 network, possibly impacting viral infection and disease progression.
Article Abstract
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spillover infection in December 2019 has caused an unprecedented pandemic. SARS-CoV-2, as other coronaviruses, binds its target cells through the angiotensin-converting enzyme 2 (ACE2) receptor. Accordingly, this makes ACE2 research essential for understanding the zoonotic nature of coronaviruses and identifying novel drugs. Here we present a systematic analysis of the ACE2 conservation and co-evolution protein network across 1,671 eukaryotes, revealing an unexpected conservation pattern in specific metazoans, plants, fungi, and protists. We identified the co-evolved protein network and pinpointed a list of drugs that target this network by using data integration from different sources. Our computational analysis found widely used drugs such as nonsteroidal anti-inflammatory drugs and vasodilators. These drugs are expected to perturb the ACE2 network affecting infectivity as well as the pathophysiology of the disease.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7368417 | PMC |
| http://dx.doi.org/10.1016/j.isci.2020.101384 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Overexpression of lncRNA LINC00294 Induces Cell Cycle Arrest and Apoptosis in Colorectal Cancer by Regulating the miR-499a-5p/LARP4B Axis.
J Biochem Mol Toxicol
January 2025
Department of Surgical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Increasing long noncoding RNAs (lncRNAs) have been found to participate in regulating the progression of colorectal cancer (CRC), which is a common gastrointestinal malignancy. Here, the specific role and mechanisms of lncRNA LINC00294 were investigated in CRC. The expression levels of LINC00294, miR-499a-5p, and La-related protein 4B (LARP4B) in CRC cells (HCT116 and SW620) and tissues were assessed by RT-qPCR.
View Article and Find Full Text PDFMetal accumulation in fish species of a vast hydrographic network in the Moyen-Ogooué and Haut-Ogooué Provinces of Gabon: Implications for human health.
Toxicol Rep
December 2024
Department of Zootechnology, University of Science and Technology of Masuku, P.O Box 941, Franceville, Gabon.
With an obsolete livestock sector, Gabon relies on its huge hydrographic network rich in fish to supply its populations with animal proteins. This study aimed to conduct metal analyses in four fish species () frequently consumed by human populations in the Moyen-Ogooué and Haut-Ogooué Provinces of Gabon and infer the potential human health risks for those populations who rely on these freshwater produces as a source of proteins. Fish were sampled from Ezanga, Oguemoué, Onangué, Nguenè (Moyen-Ogooué) and Grand Poubara (Haut-Ogooué) Lakes during the high flow period (HF) and low flow period (LF) from 2021 to 2022, and analysed for seven heavy metals (HMs) using Inductively Coupled Plasma Optical Emission Spectroscopy (ICP-OES) techniques.
View Article and Find Full Text PDFT-cadherin modulates adipogenic differentiation in mesenchymal stem cells: insights into ligand interactions.
Front Cell Dev Biol
December 2024
Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia.
Introduction: T-cadherin, a non-canonical member of the cadherin superfamily, was initially identified for its involvement in homophilic recognition within the nervous and vascular systems. Apart from its adhesive function, T-cadherin acts as a receptor for two ligands: LDL, contributing to atherogenic processes, and HMW adiponectin, a hormone with well-known cardiovascular protective properties. However, the precise role of T-cadherin in adipose tissue remains elusive.
View Article and Find Full Text PDFQuercetin alleviates ulcerative colitis through inhibiting CXCL8-CXCR1/2 axis: a network and transcriptome analysis.
Front Pharmacol
December 2024
School of Basic Medical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, China.
Introduction: Ulcerative colitis (UC) is a chronic inflammatory condition of the intestinal tract in which mucosal healing is a crucial measure of therapeutic efficacy. Quercetin, a flavonoid prevalent in various foods and traditional Chinese medicines, exhibits notable pharmacological properties, including antioxidant and anti-inflammatory activities. Consequently, it warrants investigation to determine its potential therapeutic effects on UC.
View Article and Find Full Text PDFSynergistic combinations of for myocardial infarction treatment: network pharmacology and quadratic optimization approach.
Front Pharmacol
December 2024
School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China.
Background And Aim: (Oliv.) Diels (Danggui, DG), exhibits potential in myocardial infarction (MI) treatment. However, research on its synergistic combinations for cardioprotective effects has been limited owing to inadequate approaches.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!