We studied the effect of turmeric extract in the composition of rectal suppositories on the level of LPO products and oxidative modification of proteins in the colon mucosa of Wistar rats with experimental Crohn's disease modeled by rectal administration of trinitrobenzenesulfonic acid. The suppositories containing turmeric extract were administered 12 h after disease induction. On days 3, 5, and 7 of the experiment, clinical parameters of the disease were scored using disease activity scale (DAI) and the concentration of LPO products and intensity of oxidative modification of proteins were measured by the extraction-spectrofluorimetric method. Administration turmeric extract in rectal suppositories reduced the severity of clinical symptoms, the level of LPO products (mostly in the isopropanol phase of the lipid extract), and the total content of products of oxidative modification of proteins. Moreover, correlations between DAI and concentration of LPO products in the colon were found.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-020-04883-w | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Development of ultrasonic-assisted gelatin-based biodegradable packaging film incorporated with turmeric extract for the shelf-life extension of chicken minced meat.
Int J Biol Macromol
March 2025
Department of Food Science, Government College University Faisalabad, Pakistan. Electronic address:
This study aims to develop the gelatin-based packaging film incorporated with turmeric extract to enhance the shelf life of a minced chicken. The films were subjected to functional, morphological and physicochemical characterization. The results showed that ethanolic extract of turmeric has a higher amount of turmerone and ar-turmerone along with some other bioactive compounds.
View Article and Find Full Text PDFGreen synthesis of silver nanoparticles using neem and turmeric extract and its antimicrobial activity of plant mediated silver nanoparticles.
J Oral Biol Craniofac Res
February 2025
Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, 600077, TN, India.
Introduction: The green synthesis of silver nanoparticles has gained attention for being environmentally friendly and cost-effective. This study investigates the synthesis of silver nanoparticles using neem and turmeric extracts, which serve as natural reducing and capping agents, with a focus on characterizing these nanoparticles and assessing their antimicrobial properties against oral pathogens.
Materials And Methods: Neem and turmeric extracts were prepared by heating their powdered forms in distilled water, followed by filtration.
Positive Effect of Lecithin-Based Delivery Form of Curcuma and Boswellia Extracts on Irritable Bowel Syndrome After COVID-19 Infection.
Nutrients
February 2025
Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy.
: Post-COVID-19 irritable bowel syndrome (PCIBS) is a frequent finding and is frequently associated with enteral dysbiosis. This pilot study compared the effects of extracts from curcuma and boswellia on PCIBS and irritable bowel syndrome (IBS) in individuals who had never had a COVID-19 infection (controls). : A total of 16 subjects with PCIBS and 28 controls with evidence of IBS gastrointestinal symptoms and with enteral dysbiosis were recruited and supplemented for 30 days with sunflower-lecithin-based formulations of extracts of (500 mg) and (150 mg) b.
View Article and Find Full Text PDFInvestigating the Impact of Turmeric on Neuroinflammation and Degenerative Changes in Repetitive Traumatic Brain Injuries: Insights from Murine Model.
Korean J Neurotrauma
January 2025
Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.
Objective: Traumatic brain injury (TBI) is a leading cause of death and disability worldwide. Preclinical and clinical studies investigating the effects of curcumin on TBI indicate that curcumin can modulate essential signaling pathways and molecules that mediate neuroinflammation in TBI. This study aimed to explore the effects of turmeric on neuroinflammation and neurodegenerative disorder following repetitive traumatic brain injuries (rTBIs) in a rat model.
View Article and Find Full Text PDFEvaluation of Smear Layer Removal and Antimicrobial Efficacy of Intracanal Herbal Irrigants.
J Pharm Bioallied Sci
December 2024
Department of Restorative, Endodontic Division, Faculty of Dentistry, Najran University, Kingdom of Saudi Arabia.
Background: The removal of the smear layer and antimicrobial efficacy are critical factors in endodontic treatment. Conventional chemical irrigants like sodium hypochlorite (NaOCl) and ethylenediaminetetraacetic acid (EDTA) have proven effective but can have adverse effects.
Materials And Methods: A total of 60 extracted single-rooted human teeth were randomly assigned to four groups of 15 each.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!