Suppresses Mushroom Body-Dependent Memory Consolidation in .

MicroRNAs (miRNAs) fine tune gene expression to regulate many aspects of nervous system physiology. Here, we show that suppresses memory consolidation that occurs in the αβ and γ mushroom body neurons (MBns) of , making a memory suppressor miRNA. Bioinformatics analyses suggested that mRNAs encoding kinesin heavy chain 73 (KHC73), a protein that belongs to Kinesin-3 family of anterograde motor proteins, may be a functional target of Behavioral studies that employed expression of with and without its 3' untranslated region (UTR) containing target sites, luciferase assays in HEK cells with reporters containing wild-type and mutant target sequences in the 3'UTR, and immunohistochemistry experiments involving KHC73 expression with and without the wild-type 3'UTR, all point to the conclusion that is a major target of in its functional role as a miRNA memory suppressor gene.