Modified early warning score-based clinical decision support: cost impact and clinical outcomes in sepsis.

Objective: The objective of this study was to assess the clinical and financial impact of a quality improvement project that utilized a modified Early Warning Score (mEWS)-based clinical decision support intervention targeting early recognition of sepsis decompensation.

Materials And Methods: We conducted a retrospective, interrupted time series study on all adult patients who received a diagnosis of sepsis and were exposed to an acute care floor with the intervention. Primary outcomes (total direct cost, length of stay [LOS], and mortality) were aggregated for each study month for the post-intervention period (March 1, 2016-February 28, 2017,  = 2118 visits) and compared to the pre-intervention period (November 1, 2014-October 31, 2015,  = 1546 visits).

Results: The intervention was associated with a decrease in median total direct cost and hospital LOS by 23% ( = .047) and .63 days ( = .059), respectively. There was no significant change in mortality.

Discussion: The implementation of an mEWS-based clinical decision support system in eight acute care floors at an academic medical center was associated with reduced total direct cost and LOS for patients hospitalized with sepsis. This was seen without an associated increase in intensive care unit utilization or broad-spectrum antibiotic use.

Conclusion: An automated sepsis decompensation detection system has the potential to improve clinical and financial outcomes such as LOS and total direct cost. Further evaluation is needed to validate generalizability and to understand the relative importance of individual elements of the intervention.