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Mucosal Spread of Sinonasal Adenocarcinoma into the Nasolacrimal Duct Without Bony Erosion of the Nasolacrimal Canal: A Case Report.
Ophthalmic Plast Reconstr Surg
November 2024
Department of Otolaryngology, Head and Neck Surgery, The Queen Elizabeth Hospital, Woodville South, South Australia, Australia.
Sinonasal malignancy is a rare but recognized cause for nasolacrimal obstruction leading to epiphora. While direct mucosal spread through the nasolacrimal duct can occur in benign sinonasal tumors such as inverting papilloma, the same phenomenon has not been described in malignant lesions. The authors present a case of a low-grade nonintestinal type sinonasal adenocarcinoma centered on the inferior meatus of the sinonasal cavity, showing mucosal invasion into the nasolacrimal duct with bony expansion but no erosion of the nasolacrimal canal.
View Article and Find Full Text PDFLow-Grade Non-intestinal Type Sinonasal Adenocarcinoma: A Case Report.
Cureus
October 2024
Otolaryngology and Head and Neck Surgery, King Faisal Specialist Hospital and Research Center, Riyadh, SAU.
Sinonasal non-intestinal-type adenocarcinomas represent a rare subset of head and neck cancers with distinct pathological and clinical characteristics. Patients usually present with nasal obstruction, epistaxis, and rhinorrhea. The diagnosis is established through histopathological examination.
View Article and Find Full Text PDFSinonasal Adenocarcinomas: An Update.
Surg Pathol Clin
December 2024
Department of Translational Research, Section of Pathology, University of Pisa 56124, Italy. Electronic address:
Article Synopsis
- Adenocarcinomas are the second most common sinonasal malignancies, following squamous cell carcinoma.
- They include various subtypes such as intestinal-type adenocarcinoma (ITAC) and non-intestinal-type adenocarcinomas (non-ITACs).
- ITAC resembles gastrointestinal cancers with diverse growth patterns and mucin production, while non-ITACs lack clear histopathological features and are mainly diagnosed by exclusion.
FGFR3::TACC3 fusions in head and neck carcinomas: a study of nine cases highlighting phenotypic heterogeneity, frequent HPV association, and a morphologically distinct subset in favor of a putative entity.
Virchows Arch
October 2024
Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.
The FGFR3::TACC3 fusion has been reported in subsets of diverse cancers including urothelial and squamous cell carcinomas (SCC). However, the morphology of FGFR3::TACC3-positive head and neck carcinomas has not been well studied and it is unclear if this fusion represents a random event, or if it might characterize a morphologically distinct tumor type. We describe nine FGFR3::TACC3 fusion-positive head and neck carcinomas affecting six males and three females aged 38 to 89 years (median, 59).
View Article and Find Full Text PDFConservative Lymph Node Sampling Is Clinically Appropriate in Intestinal Resections Related to Nonneoplastic Inflammatory Bowel Disease.
Arch Pathol Lab Med
September 2024
From the Department of Pathology, Johns Hopkins University School of Medicine, Baltimore Maryland. Mayer is currently in the Department of Pathology at the Sheba Medical Center, Ramat Gan, Israel.
Context.—: In this era of health care challenges, efficient resource use is crucial. Patients with inflammatory bowel disease (IBD) may undergo surgery owing to treatment-refractory disease or strictures.
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