Objective: The aim: To study health status among the children in connection with a prolonged exposure of drinking water from decentralized systems.
Patients And Methods: Materials and methods: The prevalence rates of diseases among children of rural areas were studied according to the statistical reports in Dnipropetrovsk region healthinformation center from 2008 to 2013 using statistical form № 12 (totally 220 reports). The distribution of rural areas in the region was based on the cluster analysis. The horizontal dendrogram showing similarity between the research areas in a multidimensional space. Cluster analysis includes 2 groups of rural districts in Dnipropetrovsk region.
Results: Results: It is established that with increase of pH#62; 7.5-7.6 in water of decentralized systems decreased the prevalence in the majority of nosologies: diseases of the blood and hematopoietic organs (rS=0,331; p#60;0,001), musculoskeletal system (rS=-0,174; p#60;0,001), anemia (rS=-0,331; p#60;0,001), congenital anomalies (rS=-0,272; p=0,002) among children population.
Conclusion: Conclusions: Among those children, who consumed drinking water from wells with content of some essential trace elements on the limits of MPC: 71% did not suffer from chronic diseases of the circulatory system (Fe >0.144 mg/dm3); 59% did not suffer from the diseases of digestive system (Cu #62;0.089 mg/dm3), and 60% had no congenital abnormalities of circulatory system (Mn #62; 0.099 mg/dm3).
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Chemosphere
January 2025
Faculty of Engineering, Hokkaido University, N13W8, Sapporo, 060-8628, Japan. Electronic address:
Global concern regarding transformation products (TPs) derived from contaminants, including pesticides, in the environment and during water treatment has been growing markedly. In the present study, we investigated the anti-acetylcholinesterase (AChE) activity of an aqueous solution of the organophosphorus insecticide disulfoton, a toxicological endpoint for determining the acceptable daily intake of disulfoton, both in the presence and the absence of metabolism during chlorination. Disulfoton rapidly reacted with free chlorine and completely disappeared within 0.
View Article and Find Full Text PDFJ Occup Environ Hyg
January 2025
Human and Environmental Physiology Research Unit, School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.
With mines extending deeper and rising surface temperatures, workers are exposed to hotter environments. This study aimed to characterize heat stress and strain in the Canadian mining industry and evaluate the utility of the Heat Strain Score Index (HSSI), combined with additional self-reported adverse health outcomes. An exploratory web-based survey was conducted among workers ( = 119) in the Canadian mining industry.
View Article and Find Full Text PDFTissue Eng Regen Med
January 2025
Department of Pediatrics, College of Medicine, Ewha Womans University, Seoul, 07804, South Korea.
Background: Exogenous Cushing's syndrome, which results from prolonged glucocorticoid treatment, is associated with metabolic abnormalities. Previously, we reported the inhibitory effect of tonsil-derived mesenchymal stem cell conditioned medium (T-MSC CM) on glucocorticoid signal transduction. In this study, we investigated the therapeutic efficacy of T-MSCs in a mouse model of exogenous Cushing's syndrome.
View Article and Find Full Text PDFEnviron Geochem Health
January 2025
Environment Research Laboratory, Faculty of Science, Nepal Academy of Science and Technology, Khumaltar, Lalitpur, Nepal.
A comprehensive hydrogeochemical analysis of 156 groundwater samples (106 shallow and 50 deep) was conducted in the Kathmandu Valley, Nepal. This study addresses a significant research gap by focusing on the hydro-geochemical composition and contamination of groundwater in the Kathmandu Valley, an area with limited detailed assessments. The novelty of this work lies in its comprehensive analysis of both shallow and deep groundwater, particularly concerning the high concentration of contaminants like arsenic, microbial pathogens, and ammonium, which are critical for public health.
View Article and Find Full Text PDFUrol Res Pract
January 2025
Department of Pharmacology, Ankara University, Faculty of Pharmacy, Ankara, Türkiye.
Objective: To investigate the effects of testosterone (T) treatment, with or without levothyroxine, the most widely used and least effective medication for managing hypothyroidism, on the functional and histological changes in propylthiouracil (PTU)- induced hypothyroid rat bladders.
Methods: Male rats (n=35) were split into control, hypothyroid, hypothyroid rats treated with levothyroxine (20 µg/kg/day, oral, 2-weeks), hypothyroid rats treated with Sustanon (10 mg/kg,iIM, once/week, 2-weeks), and hypothyroid rats treated with combined treatment groups. Hypothyroidism was induced by PTU (0.
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