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| http://dx.doi.org/10.1371/journal.pntd.0008302 | DOI Listing |
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Safety and Vision Outcomes Following Gene Therapy for Bietti Crystalline Dystrophy: A Nonrandomized Clinical Trial.
JAMA Ophthalmol
January 2025
Xiamen Eye Center of Xiamen University, Xiamen, Fujian, China.
Importance: Bietti crystalline dystrophy (BCD) is a severe genetic retinopathy caused by variants in the CYP4V2 gene. Currently, there is no approved treatment for BCD.
Objective: To evaluate safety and vision outcomes following gene therapy with adeno-associated virus (AAV) encoding CYP4V2 (rAAV-hCYP4V2, NGGT001 [Next Generation Gene Therapeutics]).
Background: Primary progressive aphasia (PPA) is a language-led dementia associated with underlying Alzheimer's disease (AD) or frontotemporal lobar degeneration pathology. As part of the Alzheimer's spectrum, logopenic (lv) PPA may be particularly difficult to distinguish from amnestic AD, due to overlapping clinical features. Analysis of linguistic and acoustic variables derived from connected speech has shown promise as a diagnostic tool for differentiating dementia subtypes.
View Article and Find Full Text PDFMachine Learning Approach for Sepsis Risk Assessment in Ischemic Stroke Patients.
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January 2025
Department of Pediatrics and Adolescent Gynecology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
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View Article and Find Full Text PDFBackground: The growth of social media and the continuous improvement of machine-learning algorithms suggest that social media-based screening methods for mental diseases will become increasingly feasible with high accuracy in the next few years. Additionally, Artificial Intelligence, particularly predictive machine learning (ML) Models, has been established as one of the more powerful approaches to building reliable models that might be useful as an early predictor for Mental disorders. Specifically, one of the current challenges in brain disorders is identifying patients with Mild Cognitive Impairment (MCI) that might be converted to Alzheimer's (AD) or other types of dementia.
View Article and Find Full Text PDFAlzheimer's Imaging Consortium.
Alzheimers Dement
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Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Background: Dementia poses a significant global crisis, yet 60% of cases go undetected, particularly among specific sub-populations. Timely diagnosis is crucial for implementing early intervention strategies. Challenges of current screening tools (e.
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