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Patient-Reported Outcomes in Children With Idiopathic Clubfoot Deformity Treated With Ponseti Casting: Does Recurrence of the Deformity Play a Role?
J Am Acad Orthop Surg
January 2025
From the Department of Orthopaedics, Washington University School of Medicine, St. Louis, MO.
Introduction: Despite the high effectiveness of Ponseti casting in treating idiopathic clubfoot, patient-reported outcomes (PROs) are not studied well in the literature, necessitating further investigation into PROs to evaluate the effect on patients' lives. We used the Patient-Reported Outcomes Measurement Information System (PROMIS) to evaluate PROs in children with Ponseti-treated clubfoot and assess the effect of recurrence on these PROs.
Methods: This study retrospectively reviewed medical records from patients ages 5 to 18 years treated for idiopathic clubfoot at a single institution from 2002 to 2023 with available PROMIS data for mobility, pain, and peer relationships.
Work-Stressors and Depression and Anxiety-A Longitudinal Study of the Moderating Role of Self-Compassion.
Stress Health
February 2025
Department of Psychology, Health and Technoly, Faculty of Behavioural, Management and Social Sciences, University of Twente, Enschede, the Netherlands.
Self-compassion has been defined as being open to one's suffering, not avoiding or disconnecting from it, coupled with the kind and caring motivation to alleviate one's suffering. There is increasing evidence that self-compassion might function as a buffer against the negative mental health effects of experiencing work-stressors. However, while this moderating role of self-compassion has been demonstrated when measures of subjective stress are used, different studies that use measures of more objective potential stressors failed to demonstrate a moderating role of self-compassion.
View Article and Find Full Text PDFInhibition of Retinal Neovascularization by BEZ235: Targeting the Akt/4EBP1/Cyclin D1 Pathway in Endothelial Cells.
Invest Ophthalmol Vis Sci
January 2025
Institute of Ophthalmology, School of Medicine, Jinan University, Guangzhou, China.
Purpose: To investigate the therapeutic efficacy of BEZ235, a dual PI3K/mTOR inhibitor, in suppressing pathological neovascularization in an oxygen-induced retinopathy (OIR) mouse model and explore the role of cyclin D1 in endothelial cell cycle regulation.
Methods: Single-cell RNA sequencing was performed to analyze gene expression and cell-cycle alterations in retinal endothelial cells under normoxic and OIR conditions. The effects of BEZ235 on human umbilical vein endothelial cells (HUVECs) and human retinal microvascular endothelial cells (HRMECs) were evaluated by assessing cell viability, cell-cycle progression, proliferation, migration, and tube formation.
The Digital Health Competencies in Medical Education Framework: An International Consensus Statement Based on a Delphi Study.
JAMA Netw Open
January 2025
Faculty of Medicine, Sana'a University, Sana'a, Yemen.
Importance: Rapid digitalization of health care and a dearth of digital health education for medical students and junior physicians worldwide means there is an imperative for more training in this dynamic and evolving field.
Objective: To develop an evidence-informed, consensus-guided, adaptable digital health competencies framework for the design and development of digital health curricula in medical institutions globally.
Evidence Review: A core group was assembled to oversee the development of the Digital Health Competencies in Medical Education (DECODE) framework.
Proteomic Analyses in COVID-19-Associated Secondary Hemophagocytic Lymphohistiocytosis.
Crit Care Explor
February 2025
Center for Fundamental Immunology, Benaroya Research Institute, Seattle, WA.
Context: COVID-19 has been associated with features of a cytokine storm syndrome with some patients sharing features with the hyperinflammatory disorder, secondary hemophagocytic lymphohistiocytosis (sHLH).
Hypothesis: We hypothesized that proteins associated with sHLH from other causes will be associated with COVID-sHLH and that subjects with fatal COVID-sHLH would have defects in immune-related pathways.
Methods And Models: We identified two cohorts of adult patients presenting with COVID-19 at two tertiary care hospitals in Seattle, Washington in 2020 and 2021.
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