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| http://dx.doi.org/10.1038/s41392-020-00247-y | DOI Listing |
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Multi-functional Chitosan Polymeric Micelles for improving the oral bioavailability of Paclitaxel based on synergistic effect.
Drug Deliv Transl Res
January 2025
Guangxi Institute of Botany, Chinese Academy of Sciences, No. 85 Yanshan Town, Yanshan District, Guilin, 541006, People's Republic of China.
A novel multi-functional micelle delivery system was developed for enhancing the oral absorption of paclitaxel (PTX). The delivery carriers were constructed by modifying chitosan-stearic acid (CS-SA) micelles with L-carnitine (LC) and co-encapsulating quercetin (Que), and the PTX-loaded micelles were prepared by film-sonication dispersing technique. The as-prepared micelles showed homogeneous spherical shapes with a small particle size of 148.
View Article and Find Full Text PDFInterface-Engineered Paclitaxel-Based Hollow Mesoporous Organosilica Nanoplatforms for Photothermal-Enhanced Chemotherapy of Tumor.
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December 2021
School of Pharmacy, Lanzhou University, Lanzhou 730030, Gansu, P.R. China.
Article Synopsis
- Researchers developed a biodegradable hollow mesoporous organosilica nanoparticle (HMON)-based nanoplatform for anticancer treatment, which combines chemotherapy and photothermal therapy.
- This new system can co-deliver paclitaxel and a photothermal agent (IR820) more effectively than previous methods, featuring a high drug-loading capacity of 28.4%.
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Identified the novel resistant biomarkers for taxane-based therapy for triple-negative breast cancer.
Int J Med Sci
December 2021
Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ROC.
Developing treatment strategies for triple-negative breast cancer (TNBC) has become an important clinical challenge. Currently, taxane-based chemotherapy is one of the standard treatments for TNBC. However, determining the key factor of taxane-resistance is urgently in need for clinical treatment for breast cancer.
View Article and Find Full Text PDFConstruction of paclitaxel-based antibody-drug conjugates with a PEGylated linker to achieve superior therapeutic index.
Signal Transduct Target Ther
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Biotherapeutics Discovery Research Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 200126, China.
A Paclitaxel-Based Mucoadhesive Nanogel with Multivalent Interactions for Cervical Cancer Therapy.
Small
November 2019
School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai, 200240, P. R. China.
Cervical cancer treatment is subject to limited drug access to locally diseased targets and generally resistant to chemotherapy, thus it is essential to develop a local drug delivery system to overcome these problems, premised on guaranteeing drug efficacy. With this goal in mind, a multivalent interactions-based mucoadhesive nanogel for vaginal delivery is proposed. Briefly, the nanogel is constructed with mucoadhesive poly(acrylic acid) as the backbone and multiple inclusions between β-cyclodextrin and paclitaxel as the crosslinking points.
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