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The field of single nanoparticle plasmonics has grown enormously. There is no doubt that a wide diversity of the nanoplasmonic techniques and nanostructures represents a tremendous opportunity for fundamental biomedical studies as well as sensing and imaging applications. Single nanoparticle plasmonic biosensors are efficient in label-free single-molecule detection, as well as in monitoring real-time binding events of even several biomolecules. In the present review, we have discussed the prominent advantages and advances in single particle characterization and synthesis as well as new insight into and information on biomedical diagnosis uniquely obtained using single particle approaches. The approaches include the fundamental studies of nanoplasmonic behavior, two typical methods based on refractive index change and characteristic light intensity change, exciting innovations of synthetic strategies for new plasmonic nanostructures, and practical applications using single particle sensing, imaging, and tracking. The basic sphere and rod nanostructures are the focus of extensive investigations in biomedicine, while they can be programmed into algorithmic assemblies for novel plasmonic diagnosis. Design of single nanoparticles for the detection of single biomolecules will have far-reaching consequences in biomedical diagnosis.
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http://dx.doi.org/10.1039/d0tb00351d | DOI Listing |
Psychophysiology
March 2025
Department of Neurology, Neurocybernetics and Rehabilitation, Otto von Guericke University, Magdeburg, Germany.
Prospective memory (PM) is the ability to remember to execute future intentions. PM requires engagement of attentional networks, in which oscillatory activity in the alpha frequency range has been implicated. The left dorsolateral prefrontal cortex (DLPFC) and inferior parietal cortex are assumed to be engaged during PM tasks.
View Article and Find Full Text PDFDig Liver Dis
March 2025
Endoscopy Unit, Hospital Clínic de Barcelona, Universitat de Barcelona (UB), Barcelona, Spain; Departament de Medicina, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain; Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Spain.
Background: Endoscopic forceps biopsy is the primary method for obtaining mucosal tissues, but can lead to false negatives.
Aims: To assess the agreement between endoscopic biopsies and submucosal dissection specimens in esophageal and gastric epithelial lesions and to identify factors associated.
Methods: Cross-sectional study using data from the Spanish national multicenter endoscopic submucosal dissection register.
J Small Anim Pract
March 2025
Department of Morphology, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Las Palmas, Spain.
Pathological bone fractures may occur secondarily to Cushing's syndrome in people. Although low bone mineral density due to cortisol excess has been described in dogs, there is no evidence that dogs with Cushing's disease can develop osteoporosis or secondary bone fractures. Here, we report a case of a dog with Cushing's disease and multiple pathological bone fractures.
View Article and Find Full Text PDFBMJ Open
March 2025
Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea
Introduction: Cerebral palsy (CP) is a leading cause of motor developmental disability in children. Generating epidemiological data on CP could enable early diagnosis, intervention and translational research. We aim to establish a Korean network and online data repository for CP called the Korean Cerebral Palsy Registry (KCPR).
View Article and Find Full Text PDFDiving Hyperb Med
March 2025
Navy Experimental Diving Unit, Panama City, Florida, USA.
Introduction: Venous gas emboli (VGE) are a common surrogate experimental endpoint for decompression sickness (DCS). VGE numbers are graded, and the peak post-dive grade is associated with the probability of DCS (PDCS). VGE are typically graded with the subject at rest when bubble numbers are stable, and again after limb flexions which elicit a transient shower of bubbles.
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