Background: Tuberculosis (TB) is a public health concern, especially in resource-constrained countries like Cameroon. TB drug resistance is a major obstacle to control and prevent.
Design: Data from 2014 to 2016 on the outcome of anti-TB treatment in the Littoral Region were reviewed manually and analysed using the meta-analysis concept. The treatment success rates (TSR) were the primary outcome used for this study. The heterogeneity statistics ( ) was computed to orientate the choice of the best statistical model (binary fixed effect or random) to compute pooled value of TSR.
Results: Using an intention-to-treat analysis, the pooled proportions of HIV-uninfected TB patients successfully cured from TB were low and slightly decreased by 1% between 2014 and 2016. Regarding HIV-infected TB patients, pooled values of TSR were lower than those of their HIV-negative counterparts with values ranging from 71% (95% CI: 63%-83%; = 71.16%) in 2014 to 68% (95% CI: 58%-79%; = 70.97%) in 2016. In addition, no heterogeneity was found in three years ( = 0.0%; value = 1). These cure rates were strongly and negatively correlated with the rates of patients lost to follow-up regardless of the year. In HIV-infected patients, the pooled values of ITT analysis-based treatment success rates were 73% ( = 13.92, value = 0.0002), 71% ( = 7.26, value = 0.007), and 68% ( = 8.02, value = 0.004), respectively. The coverage rates with cotrimoxazole (CTX) gradually increased over year ranging from 78.90% in 2014 to 94.17% in 2016, similar to the coverage rate for ARV therapy that was 60.06% in 2014 against 90% in 2016. A positive and statistically significant correlation was found between the success of the anti-TB therapy in HIV-infected patients and coverage rates with CTX and ARV.
Conclusion: An improvement in the reduction of percentage of lost to follow-up and coverage with CTX and ARV therapy could greatly increase chances to efficiently control TB in Cameroon.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7366214 | PMC |
| http://dx.doi.org/10.1155/2020/8298291 | DOI Listing |
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