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Identification and distribution of nine tick-borne spotted fever group Rickettsiae in the Country of Georgia. | LitMetric

AI Article Synopsis

  • Rickettsial pathogens cause various diseases, mainly linked to febrile conditions, with several species transmitted by ticks, particularly in Georgia.
  • A study analyzed 1594 ticks from different regions of Georgia, leading to the identification of nine Rickettsia species, including human pathogens and some with unknown impacts.
  • Molecular methods like qPCR and multi-locus sequence typing revealed new endemic regions in Georgia where these tick-borne rickettsiae are present, enhancing the understanding of their distribution.

Article Abstract

Rickettsial pathogens cause diseases that vary in severity and clinical presentation. Rickettsia species transmitted by ticks are mostly classified within the spotted fever group of rickettsiae (SFGR) and are often associated with febrile diseases. Preliminary studies have detected three human-pathogenic SFGR from ticks in Georgia: Rickettsia aeschlimannii, Rickettsia raoultii, and Rickettsia slovaca. To more broadly assess the presence of tick-borne rickettsiae from Georgia we examined 1594 ticks, representing 18 species from five genera (Ixodes, Hyalomma, Haemaphysalis, Dermacentor, and Rhipicephalus), collected from eight regions of Georgia. A total of 498 tick DNA samples extracted from single ticks or pooled ticks were assessed by molecular methods. Genus-specific Rick17b and species-specific qPCR assays were used to identify six rickettsiae: R. aeschlimannii, R. raoultii, R. slovaca, Rickettsia conorii subsp. conorii, Rickettsia massiliae, and Rickettsia monacensis. Tick samples that were positive for Rickettsia, but not identified by the species-specific assays, were further evaluated by multi-locus sequence typing (MLST) using sequences of four protein-coding genes (gltA, ompA,ompB, sca4). Three additional Rickettsia species were identified by MLST: Candidatus Rickettsia barbariae, Rickettsia helvetica, and Rickettsia hoogstraalii. Overall, nine species of Rickettsia (six human pathogens and three species with unknown pathogenicity) were detected from 12 tick species of five different genera. A distribution map for the tick-borne rickettsiae revealed six newly identified endemic regions in Georgia.

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Source
http://dx.doi.org/10.1016/j.ttbdis.2020.101470DOI Listing

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