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Governing in the face of a global crisis: When do voters punish and reward incumbent governments?
Proc Natl Acad Sci U S A
January 2025
Yale Jackson School of Global Affairs, Yale University, New Haven, CT 06511.
The recent COVID-19 pandemic offers a rare opportunity to understand how citizens attribute responsibility for governments' responses to unanticipated negative-and in this case, systemic-exogenous shocks. Classical accounts of responsibility are complicated when crises are pervasive, involve multiple valence dimensions, and where individuals can make relative assessments of performance. We fielded a conjoint experiment in 16 countries with 22,147 respondents.
View Article and Find Full Text PDFEmpowering African Expertise: Enhancing Safety Data Integration and Signal Detection for COVID-19 Vaccines Through the African Union Smart Safety Surveillance Joint Signal Management Group.
Drug Saf
January 2025
Department of Public Health Pharmacy and Management, Sefako Makgatho Health Sciences University, Pretoria, South Africa.
Introduction: The COVID-19 pandemic accelerated new vaccine development. Limited safety data necessitated robust global safety surveillance to accurately identify and promptly communicate potential safety issues. The African Union Smart Safety Surveillance (AU-3S) program established the Joint Signal Management (JSM) group to support identification of potential vaccine safety concerns in five pilot countries (Ethiopia, Ghana, Kenya, Nigeria, South Africa), accounting for approximately 35% of the African population.
View Article and Find Full Text PDFInfluence of goethite on the fate of antibiotic (tetracycline) in the aqueous environment: Effect of cationic and anionic surfactants.
Sci Total Environ
January 2025
Environmental Nanoscience Laboratory, Department of Earth Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal 741246, India; Centre for Climate and Environmental Studies, Indian Institute of Science Education and Research Kolkata, Mohanpur, West Bengal 741246, India. Electronic address:
Over the last decades, the release and occurrence of organic pollutants in aquatic systems have become a major global concern due to their bioaccumulation, toxicity, and adverse effects on the ecosystem. Tetracycline (TC), a widely used antibiotic, is often found at high concentrations in the aqueous environment and tends to bind with the natural colloids. Post-COVID-19 pandemic, the release of surfactants in the environment has increased due to the excessive use of washing and cleaning products.
View Article and Find Full Text PDFAtomic Insights into pH-Dependent and Water Permeation of mRNA-Lipid Nanoparticles.
Mol Pharm
January 2025
Research Center of the Ministry of Education for High Gravity Engineering and Technology, Beijing University of Chemical Technology, Beijing 100029, China.
The exposure of mRNA to water is likely to contribute to the instability of RNA vaccines upon storage under nonfrozen conditions. Using atomistic molecular dynamics (MD) simulations, we investigated the pH-dependent structural transition and water penetration behavior of mRNA-lipid nanoparticles (LNPs) with the compositions of Moderna and Pfizer vaccines against COVID-19 in an aqueous solution. It was revealed that the ionizable lipid (IL) membranes of LNPs were extremely sensitive to pH, and the increased acidity could cause a rapid membrane collapse and hydration swelling of LNP, confirming the high releasing efficiency of both LNP vaccines.
View Article and Find Full Text PDFIndividual and community level factors associated with household level food insecurity of Ethiopia: multilevel mixed effects analysis of 2021 Performance Monitoring for Action Ethiopia (PMA-ET).
BMC Nutr
January 2025
Lecturer of Biostatistics, Department of Public Health, College of Medicine and Health Science, Injibara University, Injibara, Ethiopia.
Background: People who face restricted or uncertain physical and economic access to safe, sufficient, and nutritious food to suit their dietary needs or food choices for a productive, healthy, and active life are said to be in a state or situation of food insecurity. There is a dearth of evidence of individual and community-level factors associated with household-level food insecurity in Ethiopia. Thus, this study aimed to assess individual and community-level factors associated with household-level food insecurity to fill the aforementioned gap.
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