AI Article Synopsis
- Unraveling the human brain's complexity is difficult, leading to the development of "brain organoids" by neurobiologists to better study brain development and neurological diseases.
- Brain organoids have limitations, such as lacking the complex neural circuitry found in human brains, but researchers are optimistic they can provide insights into brain circuit complexity and regional differences.
- This text reviews the current state of brain organoids, focusing on how they're created and their applications in modeling neurological disorders, drug discovery, and clinical testing.
Article Abstract
Unravelling the complexity of the human brain is a challenging task. Nowadays, modern neurobiologists have developed 3D model systems called "brain organoids" to overcome the technical challenges in understanding human brain development and the limitations of animal models to study neurological diseases. Certainly like most model systems in neuroscience, brain organoids too have limitations, as these minuscule brains lack the complex neuronal circuitry required to begin the operational tasks of human brain. However, researchers are hopeful that future endeavors with these 3D brain tissues could provide mechanistic insights into the generation of circuit complexity as well as reproducible creation of different regions of the human brain. Herein, we have presented the contemporary state of brain organoids with special emphasis on their mode of generation and their utility in modelling neurological disorders, drug discovery, and clinical trials.
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