AI Article Synopsis
- - The study examined the rising trend of genetic testing for lactose intolerance (LI) in North Denmark, highlighting a sevenfold increase in tests from 2007 to 2018, with a notable amount of repeated testing among individuals.
- - It analyzed the demographic factors influencing test results, revealing that 13.3% of tested individuals had the -13910 CC genotype associated with lactase deficiency, particularly higher in non-European participants (90.9%).
- - The findings indicate that patient age and geographical origin significantly impact both the usage of genetic testing and the prevalence of the genotype, contributing to the ongoing discussion about effective strategies for diagnosing LI.
Article Abstract
Objective: Lactose intolerance (LI) may be considered in patients with unspecific gastrointestinal symptoms, but there is no clear consensus on when and how to diagnose the disorder. The -13910 CC genotype is associated with acquired primary lactase deficiency (adult-type hypolactasia; ATH). We aimed to describe the number of tests and test results in the North Denmark Region considering patient age, geographical origin and repeated testing.
Methods: Retrospective evaluation of the polymerase chain reaction-based -13910 genotype tests registered in the clinical laboratory information system (LABKA II) with data linkage to Danish nationwide registers.
Results: Between 18 May 2007 and 31 December 2018, a total of 23,560 individuals were tested. There was a sevenfold increase in the number of tests performed during the study period. About 9.8% of the tests performed in 2018 were repeated testing in the same individuals. Overall, 8.8% of tested individuals were younger than 5 years, 90.7% were of Danish origin and 5.5% originated from outside of Europe. The -13910 CC genotype was identified in 13.3% of all tested individuals, in 16.0% of children younger than 5 years, in 6.8% of Danish individuals and in 90.9% originating from outside of Europe.
Conclusions: In the North Denmark Region, a marked increase in the use of genetic testing for hypolactasia was observed and repeated testing was frequent. Furthermore, the use of the test and the test results were dependent on patient age and geographical origin. Results inform the debate on when and how to use genetic testing in the diagnosing of LI.
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| http://dx.doi.org/10.1080/00365521.2020.1800079 | DOI Listing |
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