AI Article Synopsis
- Carbon-ion radiotherapy (CIRT) is effective against tumors and delivers precise doses, particularly for head-and-neck squamous cell carcinoma (HNSCC).
- HPV status influences the effectiveness of traditional photon radiotherapy for HNSCC, but its impact on CIRT sensitivity was previously unknown.
- The study found that CIRT is more beneficial for HPV-negative HNSCC cells compared to HPV-positive cells due to higher relative biological effectiveness (RBE).
Article Abstract
Carbon-ion radiotherapy (CIRT) has strong antitumor effects and excellent dose conformity. In head-and-neck squamous cell carcinoma (HNSCC), human papillomavirus (HPV) status is a prognostic factor for photon radiotherapy outcomes. However, the effect of HPV status on the sensitivity of HNSCCs to carbon ions remains unclear. Here, we showed that the relative biological effectiveness (RBE) of carbon ions over X-rays was higher in HPV-negative cells than in HSGc-C5 cells, which are used for CIRT dose establishment, whereas the RBE in HPV-positive cells was modest. These data indicate that CIRT is more advantageous in HPV-negative than in HPV-positive HNSCCs.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7565683 | PMC |
| http://dx.doi.org/10.3390/jpm10030071 | DOI Listing |
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