AI Article Synopsis
- The hematopoietic system's simplicity and similarity to vertebrate blood cell development make it a compelling area for study.
- The lymph gland serves as the primary organ for larval blood cell production, containing both stem-like progenitor cells and specialized blood cells, which require a delicate balance of maintenance and differentiation.
- Key developmental signaling pathways, including Notch, Hedgehog, and Wnt/Wingless, are crucial in regulating growth and differentiation in the lymph gland, underscoring their importance in blood cell development during larval stages.
Article Abstract
The hematopoietic system is becoming increasingly attractive for its simple blood cell lineage and its developmental and functional parallels with the vertebrate system. As the dedicated organ for larval hematopoiesis, the lymph gland harbors both multipotent stem-like progenitor cells and differentiated blood cells. The balance between progenitor maintenance and differentiation in the lymph gland must be precisely and tightly controlled. Multiple developmental signaling pathways, such as Notch, Hedgehog, and Wnt/Wingless, have been demonstrated to regulate the hematopoietic processes in the lymph gland. Focusing on blood cell maintenance and differentiation, this article summarizes the functions of several classic developmental signaling pathways for lymph gland growth and patterning, highlighting the important roles of developmental signaling during lymph gland development as well as larval hematopoiesis.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7432643 | PMC |
| http://dx.doi.org/10.3390/ijms21155246 | DOI Listing |
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