Recombinant protein targeting and opsonizing spike glycoprotein for enhancing SARS-CoV-2 phagocytosis.

Med Hypotheses

Faculty of Life and Nature Sciences, University of Brothers Mentouri Constantine, Algeria; National Center of Biotechnology Research Constantine, Algeria. Electronic address:

Published: October 2020

The present hypothesis suggests an innovative therapeutic strategy to cease Covid 19 infection. It is based on the inhibition of Spike glycoprotein and ACE-2 receptor interaction that provides the entry of virus in human host cells, by targeting the S protein with a recombinant molecule made of the ACE-2 receptor ectodomain and an opsonin, the formed complex would enhance its phagocytosis.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7358758PMC
http://dx.doi.org/10.1016/j.mehy.2020.110108DOI Listing

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