AI Article Synopsis
- Researchers have isolated and purified a new 9 amino acid neuropeptide named DPKQDFMRFamide from adult fruit flies (D. melanogaster), which is part of the FMRFamide peptide family.
- The gene for DPKQDFMRFamide has been cloned and is found as a single copy in the genome, expressed as a distinct 1.7 kb mRNA, and located on chromosome 2.
- The precursor protein consists of 347 amino acids and produces five copies of DPKQDFMRFamide along with ten additional related peptides, indicating evolutionary relationships between neuropeptides of different species.
Article Abstract
We have purified a 9 amino acid amidated neuropeptide, DPKQDFMRFamide, from whole adult D. melanogaster. This peptide exhibits sequence homology to the molluscan bioactive tetrapeptide FMRFamide and is a novel member of the FMRFamide peptide family. The gene encoding DPKQDFMRFamide has been cloned and characterized. It is present in a single copy per haploid genome, is expressed as a unique 1.7 kb mRNA species, and cytologically maps to 46C on the right arm of chromosome 2. Characterization of a cDNA clone indicates that the precursor protein is 347 amino acids in length and contains 5 copies of DPKQDFMRFamide, as well as 10 additional amidated peptides exhibiting varying degrees of structural relatedness. The Drosophila DPKQDFMRFamide gene and the Aplysia FMRFamide gene are ancestrally related; however, peptides display a higher degree of homology within a species than between species, suggesting intragenic concerted evolution of these neuropeptides.
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| http://dx.doi.org/10.1016/0896-6273(88)90209-7 | DOI Listing |
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