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| http://dx.doi.org/10.1053/j.gastro.2020.07.042 | DOI Listing |
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[Social and Health Factors Related to Treatment Discontinuity in Chilean Adults with Chronic Diseases During the COVID-19 Pandemic].
Rev Med Chil
October 2024
Escuela de Salud Pública, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Unlabelled: A collateral effect of the COVID-19 pandemic has been the discontinuity of treatments, a highly sensitive situation for chronic patients.
Aim: to describe the factors associated with discontinuing treatments in chronic patients over 18 years old residing in Chile during the COVID-19 pandemic.
Methods: A secondary analysis of the database of the MOVID-IMPACT-C survey, which corresponds to a cross-sectional study with national urban representativeness, was carried out in 2020.
Novel Isothermal Amplification Integrated with CRISPR/Cas13a and Its Applications for Ultrasensitive Detection of SARS-CoV-2.
ACS Synth Biol
February 2025
Department of Chemical and Biomolecular Engineering (BK21 Four), Korea Advanced Institute of Science and Technology (KAIST), 291 Daehak-ro, Yuseong-gu, Daejeon 34141, Republic of Korea.
We herein developed an ultrasensitive and rapid strategy to identify genomic nucleic acids by integrating a clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 13a (Cas13a) into our recently developed isothermal technique, nicking and extension chain reaction system-based amplification (NESBA) reaction. In this technique, named CESBA, the NESBA reaction isothermally produces a large amount of RNA amplicons from the initial target genomic RNA (gRNA). The RNA amplicons bind to the crispr RNA (crRNA) and activate the collateral cleavage activity of Cas13a, which would then cleave the reporter probe nearby, consequently producing the final signals.
View Article and Find Full Text PDFThe Impact of Domestic Violence and Sexual Assault on Family Dynamics and Child Development: A Comprehensive Review.
Turk Arch Pediatr
January 2025
Department of Forensic Medicine, İstanbul Health and Technology University Faculty of Medicine, İstanbul, Türkiye.
This review synthesizes current research on domestic violence and sexual assault, focusing on their short-term and long-term effects on family dynamics, particularly on the development and well-being of children and adolescents. The article employs a curated body of literature, including surveys, reviews, program evaluations, and international health reports, to elucidate the direct and collateral damage caused by such trauma within families. The review critically examines the intersecting consequences of abuse, including immediate psychological distress and long-term socio-economic and educational disruptions for affected youths.
View Article and Find Full Text PDFLeveraging Synthetic Antibody-DNA Conjugates to Expand the CRISPR-Cas12a Biosensing Toolbox.
ACS Synth Biol
January 2025
Department of Chemical Science and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica 1, 00133 Rome, Italy.
We report here the use of antibody-DNA conjugates (Ab-DNA) to activate the collateral cleavage activity of the CRISPR-Cas12a enzyme. Our findings demonstrate that Ab-DNA conjugates effectively trigger the collateral cleavage activity of CRISPR-Cas12a, enabling the transduction of antibody-mediated recognition events into fluorescence outputs. We developed two different immunoassays using an Ab-DNA as activator of Cas12a: the CRISPR-based immunosensing assay (CIA) for detecting SARS-CoV-2 spike S protein, which shows superior sensitivity compared with the traditional enzyme-linked immunosorbent assay (ELISA), and the CRISPR-based immunomagnetic assay (CIMA).
View Article and Find Full Text PDFReducing loneliness and depressive symptoms in older adults during the COVID-19 pandemic: A pre-post evaluation of a psychosocial online intervention.
PLoS One
December 2024
Epidemiology of Mental Health Disorders and Ageing Research Group, Sant Joan de Déu Research Institute, Barcelona, Esplugues de Llobregat, Spain.
Background: Loneliness is related to worse mental health, particularly in people with poor social support. The COVID-19 pandemic altered our lives and ways of social interaction, especially among vulnerable populations such as older adults.
Methods: We designed a group-based psychosocial online intervention for older adults (≥ 65 years) facilitated by gerontologists addressing loneliness consisting of: (i) sharing experiences and promoting peer support to overcome feelings of loneliness and (ii) increasing the chances of establishing successful social relationships.
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