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Acrodermatitis dysmetabolica: lessons from two pediatric cases.
J Pediatr Endocrinol Metab
January 2025
Department of Pediatrics, Konya City Hospital, University of Health Sciences, Konya, Türkiye.
Objectives: Acrodermatitis dysmetabolica (AD) is a dermatologic manifestation associated with inherited metabolic disorders (IMDs), distinct from acrodermatitis enteropathica, which occurs solely due to zinc deficiency.
Case Presentation: This report presents two pediatric cases: a 30-month-old girl with maple syrup urine disease (MSUD) experiencing AD secondary to severe isoleucine deficiency due to a protein-restricted diet, showing improvement with dietary adjustments, and a 2.5-month-old boy infant with propionic acidemia (PA) who developed AD alongside septic shock, which progressed despite intervention.
Clinical characteristics and serological profiles of Lyme disease in children: a 15-year retrospective cohort study in Switzerland.
Lancet Reg Health Eur
January 2025
Division of Infectious Diseases and Hospital Epidemiology, Children's Research Center, University Children's Hospital Zurich, University of Zurich, Zurich, Switzerland.
Background: Lyme disease (LD) is caused by and is the most common tickborne disease in the northern hemisphere. Although classical characteristics of LD are well-known, the diagnosis and treatment are often delayed. Laboratory diagnosis by serological testing is recommended for most LD manifestations.
View Article and Find Full Text PDFBridging the gap: Insights in the immunopathology of Lyme borreliosis.
Eur J Immunol
December 2024
Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato (Bbsl) genospecies transmitted by Ixodes spp. ticks, is a significant public health concern in the Northern Hemisphere. This review highlights the complex interplay between Bbsl infection and host-immune responses, impacting clinical manifestations and long-term immunity.
View Article and Find Full Text PDFAcquired and Inherited Zinc Deficiency-Related Diseases in Children: A Case Series and a Narrative Review.
Pediatr Rep
July 2024
Pediatric Emergency Room and Emergency Medicine Unit, Emergency Department, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy.
Article Synopsis
- - Zinc deficiency is a critical health issue for children, leading to a variety of health problems and conditions that can be either acquired or inherited.
- - This overview highlights the different symptoms, diagnostic difficulties, and treatment options for zinc deficiency in children, including issues like skin problems, slow growth, immune dysfunction, and neurological effects.
- - Addressing zinc deficiency requires collaboration among healthcare professionals such as pediatricians, dermatologists, geneticists, and nutritionists to improve care and outcomes for affected children.
Updates on postinfectious skin rashes in pediatric dermatology.
Curr Opin Pediatr
August 2024
Department of Dermatology and Pediatrics, University of California, Davis, California, USA.
Article Synopsis
- This review highlights updates on skin rashes following infections in children, primarily related to the COVID-19 pandemic.
- Key complications discussed include multisystem inflammatory syndrome in children (MIS-C) and reactive infectious mucocutaneous eruption (RIME), which are seen post-SARS-CoV-2 infection but mostly show low mortality rates.
- The review also addresses the increasing antifungal resistance related to Trichophyton indotinae and emphasizes the importance of staying updated on recent management guidelines for various skin conditions in pediatric care.
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