Assessment of , , and Genetic Polymorphisms in Esophageal Squamous Cell Carcinoma Susceptibility in the Eastern Chinese Han Population: A Case-Control Study Involving 2351 Subjects.

Previous studies suggested that alterations in the energy metabolism might be underlying cancer initiation and progression. Polymorphisms of genes involved in energy metabolism regulation, such as (), (), and (), might confer susceptibility to esophageal squamous cell carcinoma (ESCC) and partially explain its pathogenesis. We investigated the effects of several single nucleotide polymorphisms (SNPs) in three metabolic-related genes (e.g., , , and ) on ESCC susceptibility. In total, 829 patients with sporadic ESCC and 1522 nontumor controls were enrolled in the study. SNPs were genotyped using PCR-ligase detection reaction. Our study revealed that the rs3736265 G/A SNP significantly increased the risk for ESCC (GA vs. GG: adjusted odds ratio [OR] = 1.25, 95% confidence interval [95% CI] = 1.02-1.54,  = 0.034; GA+AA vs. GG: adjusted OR = 1.25, 95% CI = 1.03-1.52,  = 0.027]. In addition, a stratified analysis revealed that the rs3736265 SNP was correlated with the development of ESCC in male and nondrinking subgroups. We also confirmed that the rs17572019 G/A SNP promoted the risk of ESCC in subgroup with high alcohol intake. The rs8192678 C/T polymorphism decreased the susceptibility of ESCC in men. These findings highlight that polymorphisms in and may contribute to ESCC susceptibility. In the future, further well-designed epidemiological studies are needed to confirm our findings.