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Hotspots and status of Fetal Alpha-Thalassemia from 2009 to 2023: a bibliometric analysis.
Front Pediatr
December 2024
Maternity and Child Health Care of Guangxi Zhuang Autonomous Region, Nanning, China.
Objective: to evaluate the research status and development hotspots of fetal α-thalassemia by quantitatively analyzing the diagnostic status, key areas, related management measures and prospects of the disease by bibliometrics.
Methods: The global literature on fetal α-thalassemia and severe α-thalassemia from 2009-2023 in the Web of Science Core Collection (WOSCC) was visually analyzed by VOSviewer and CiteSpace.
Results: (1) The examination of the quantity of publications concerning fetal α-thalassemia indicates a rising tendency prior to 2018, followed by a decrease after 2018.
A novel method for telomere length detection in fission yeast.
FEMS Yeast Res
December 2024
Faculty of Science, Department of Molecular Biology and Genetics, Istanbul University, Istanbul, Turkey.
Fission yeast is the ideal model organism for studying telomere maintenance in higher eukaryotes. Telomere length has been directly correlated with life expectancy and the onset of aging-related diseases in mammals. In this study, we developed a novel simple, and reproducible method to measure the telomere length, by investigating the effect of Caffeine and Cisplatin on the telomere length in fission yeast.
View Article and Find Full Text PDFCerebral Hemodynamic Responses to Disease-Modifying and Curative Sickle Cell Disease Therapies.
Neurology
January 2025
From the Department of Neurology (M.A.A., W.R., A.K.S., M.J.D.), Department of Radiology and Radiological Sciences (D.M., L.T.D., L.C.J.), Division of Pediatric Neurology, Department of Pediatrics (S.M.D., L.L.M., L.C.J.), Division of Hematology and Oncology, Department of Medicine (A.A.K., M.R.D.), and Department of Psychiatry and Behavioral Sciences (M.J.D.), Vanderbilt University Medical Center, Nashville; Vanderbilt-Meharry Center of Excellence in Sickle Cell Disease (A.A.K., M.R.D.), Nashville; and Department of Electrical and Computer Engineering (M.J.D.), Vanderbilt University, Nashville, TN.
Background And Objectives: Sickle cell disease (SCD) is a hemoglobinopathy resulting in hemoglobin-S production, hemolytic anemia, and elevated stroke risk. Treatments include oral hydroxyurea, blood transfusions, and hematopoietic stem cell transplantation (HSCT). Our objective was to evaluate the neurologic relevance of these therapies by characterizing how treatment-induced changes in hemoglobin (Hb) affect brain health biomarkers.
View Article and Find Full Text PDFFunctional ovarian reserve in women with Sickle Cell disease: A systematic review.
JBRA Assist Reprod
December 2024
Public Health Department of State University of Feira de Santana, UEFS, Feira de Santana, Bahia, Brazil.
With the improvement in survival and the reduction in morbidity related to sickle cell disease (SCD), aspects related to reproductive health are emerging as a priority in the care of affected people. We conducted a systematic review looking for evidence describing the functional ovarian reserve levels in women with sickle cell disease. To locate studies, a search was performed in electronic databases, in addition to preprint servers and reference lists of selected publications.
View Article and Find Full Text PDFHydroxyurea inhibits proliferation and stimulates apoptosis through inducible nitric oxide synthase in erythroid cells.
Biomed Pharmacother
December 2024
Department of molecular oncology, Institute for Medical Research, National Institute of the Republic of Serbia, University of Belgrade, Serbia. Electronic address:
Hydroxyurea (hydroxycarbamide, HU) arrests cells in the S-phase by inhibiting ribonucleotide reductase and DNA synthesis, significantly contributing to the release of nitric oxide (NO). We investigated the involvement of inducible NO synthase (NOS2) in the cytostatic effect of HU using in vitro shRNA-induced knockdown of the NOS2 transcript (NOS2) or a specific NOS2 inhibitor (1400W) in human erythroleukemic HEL92.1.
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