Objective: This study examined the growth trajectory of fear of cancer recurrence (FCR) and its predictors, and the association of that trajectory with the beliefs and rates of medication adherence in patients with breast cancer.
Methods: Two hundred and ten patients with breast cancer undergoing adjuvant endocrine therapy in a university hospital in Seoul, Korea, were followed up five times over 18 months following surgery, and data from the final 162 patients were analyzed.
Results: Latent class growth analysis identified three classes. Classes 1 (38.31%) and 2 (39.89%) showed low and moderate FCR levels, respectively, with a decreasing trend over time. Class 3 (21.80%) showed a high FCR level with an initially decreasing but increasing trend afterward s. Lower education and unemployed status were associated with the high FCR class. Higher depression was more associated with the moderate FCR class than the low FCR class. Higher emotional representation was more associated with the high FCR class than with low FCR class, and greater illness comprehension was more associated with the moderate FCR class than with the high FCR class. Both necessity and concerns about medication were the highest in the high FCR class. However, self-reported medication adherence rates did not significantly differ between the classes.
Conclusions: A high level of FCR appears to persist over time, and given its association with greater concerns about medication, monitoring and management of FCR throughout the cancer trajectory.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/pon.5497 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effects of dietary hydroxy-cinnamic acid derivatives on growth, muscle, and intestinal parameters of Tilapia (Oreochromis niloticus).
Fish Physiol Biochem
January 2025
Key Laboratory for Animal Nutrition and Feed Science of Hubei Province, Wuhan Polytechnic University, Wuhan, 430000, China.
Hydroxycinnamic acid derivatives are a class of phenolic acid compounds, including sinapic acid, ferulic acid, and caffeic acid, which are widely found in plants. This experiment was conducted to study the effects of hydroxycinnamic acid derivatives (sinapic acid, ferulic acid, and caffeic acid) on the growth performance, muscle physical parameters, and intestinal morphology of tilapia. A total of 320 tilapia fingerlings (9.
View Article and Find Full Text PDFAntibodies to the RBD of SARS-CoV-2 spike mediate productive infection of primary human macrophages.
Nat Commun
December 2024
Department of Infectious Diseases, School of Immunology & Microbial Sciences, King's College London, London, SE1 9RT, UK.
The role of myeloid cells in the pathogenesis of SARS-CoV-2 is well established, in particular as drivers of cytokine production and systemic inflammation characteristic of severe COVID-19. However, the potential for myeloid cells to act as bona fide targets of productive SARS-CoV-2 infection, and the specifics of entry, remain unclear. Using a panel of anti-SARS-CoV-2 monoclonal antibodies (mAbs) we performed a detailed assessment of antibody-mediated infection of monocytes/macrophages.
View Article and Find Full Text PDFThree-year trajectories and associated factors of fear of cancer recurrence in newly diagnosed head and neck cancer patients: a longitudinal study.
J Cancer Surviv
December 2024
Department of Medical Psychology, Radboud University Medical Center, Nijmegen, The Netherlands.
Purpose: Limited data exists on the long-term course of fear of cancer recurrence (FCR) in head and neck cancer (HNC) patients. One in five patients was found to experience persistent high FCR in the first months after diagnosis. This study assessed the 3-year trajectories and associated factors of FCR in newly diagnosed HNC patients.
View Article and Find Full Text PDFHumoral signatures of Caspr2-antibody spectrum disorder track with clinical phenotypes and outcomes.
Med
October 2024
Department of Neurology with Institute of Translational Neurology, University Hospital Münster, Münster, Germany. Electronic address:
Article Synopsis
- IgG4 auto-antibodies targeting Caspr2 are linked to various neurological symptoms, but the exact mechanisms of how they cause neuronal dysfunction are not fully understood.
- The study identifies two distinct biosignatures related to clinical phenotypes: limbic encephalitis (LE) and peripheral nerve hyperexcitability, with specific immune features associated with each condition.
- Findings suggest that the presence of IgG1 antibodies and their pro-inflammatory effects are crucial for the development of LE, indicating that therapies targeting these pathways could improve patient outcomes.
Article Synopsis
- Shigellosis is a major cause of diarrheal deaths in children under five, and there's currently no effective vaccine for Shigella infection, particularly in endemic areas.
- Researchers in Bangladesh studied the antibody responses in both young children and older individuals with confirmed shigellosis to understand the differences in immune response.
- Findings revealed that while higher antibody levels correlated with less severe disease, young children developed weaker and less effective immune responses compared to older individuals, which may hinder their ability to fight off Shigella effectively.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!