We analyzed 312 drug-resistant genomes of isolates collected from HIV-coinfected and HIV-negative TB patients from nine countries with a high tuberculosis burden. We found that rifampicin-resistant strains isolated from HIV-coinfected patients carried disproportionally more resistance-conferring mutations in that are associated with a low fitness in the absence of the drug, suggesting these low-fitness variants can thrive in the context of reduced host immunity.
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| http://dx.doi.org/10.1128/AAC.00782-20 | DOI Listing |
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