Efficacy of Ibrexafungerp (SCY-078) against Candida auris in an Guinea Pig Cutaneous Infection Model.

Antimicrob Agents Chemother

Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, Ohio, USA.

Published: September 2020

has been shown to have a high risk of skin colonization in hospitalized patients, possibly contributing to nosocomial spread. In a guinea pig skin model, animals were evaluated for clinical appearance, tissue fungal burden, histology, and pharmacokinetics. Oral dosing with 10 mg/kg ibrexafungerp (IBX) reduced the severity of lesions and significantly reduced the fungal burden in infected animals compared with untreated controls. This indicates promise for use of IBX in controlling skin infection and colonization of hospitalized patients.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7508588PMC
http://dx.doi.org/10.1128/AAC.00854-20DOI Listing

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