AI Article Synopsis
- MicroRNAs (miRNAs) are key players in the development of anaplastic thyroid carcinoma (ATC), with miR-199a-5p showing promise as a tumor suppressor.
- Research indicates that miR-199a-5p is significantly reduced in ATC tissues, and its increased levels can hinder cell migration and invasion, as well as lung metastasis.
- The findings suggest that miR-199a-5p inhibits epithelial-mesenchymal transition (EMT) by targeting Snail, indicating that manipulating this pathway could be a new strategy to combat ATC metastasis.
Article Abstract
MicroRNAs (miRNAs) have been validated to play prominent roles in the occurrence and development of anaplastic thyroid carcinoma (ATC). miR-199a-5p was previously reported to act as a tumor suppressor or oncomiRNA in various types of cancer. However, its accurate expression, function, and mechanism in ATC remain unclear. Here, we find that miR-199a-5p is significantly downregulated in ATC tissues compared with adjacent non-cancerous tissues. Overexpression of miR-199a-5p significantly inhibits migration and invasion of ATC cells in vitro, and lung metastasis in vivo. Importantly, miR-199a-5p suppresses epithelial-mesenchymal transition (EMT) both in vitro and in vivo by targeting Snail. Taken together, this study reveals that miR-199a-5p is critical to the EMT progression in ATC cells. Targeting the pathway described here may be a novel approach for inhibiting metastasis of ATC.
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| http://dx.doi.org/10.3233/CBM-201518 | DOI Listing |
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