AI Article Synopsis
- Hyperlipidemia is a key risk factor for coronary artery disease, and this study investigates its genetic links in a Chinese population.
- Researchers analyzed the association of three specific SNPs in the APLP2 gene with lipid levels in 1,738 participants from Xinjiang, using a precise genotyping method.
- Results showed that SNP rs2054247 correlates with total cholesterol, LDL, and HDL levels, while SNP rs747180 is linked to total cholesterol and LDL levels, highlighting the genetic influence on lipid levels in this population.
Article Abstract
Hyperlipidemia is one of the main risk factors for coronary artery disease (CAD). In the present study, we aimed to explore whether the single-nucleotide polymorphisms (SNPs) in amyloid precursor-like protein (APLP) 2 (APLP2) gene were associated with high lipid levels in Chinese population in Xinjiang, China. We recruited 1738 subjects (1187 men, 551 women) from the First Affiliated Hospital of Xinjiang Medical University, and genotyped three SNPs (rs2054247, rs3740881 and rs747180) of APLP2 gene in all subjects by using the improved multiplex ligation detection reaction (iMLDR) method. Our study revealed that the rs2054247 SNP was associated with serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) levels, and high-density lipoprotein cholesterol (HDL-C) in additive model (all P<0.05). The rs747180 SNP was associated with serum TC and LDL-C levels in additive model (all P<0.05). Our study revealed that both rs2054247 and rs747180 SNPs of the APLP2 gene were associated with high TC and LDL-C levels in Chinese subjects in Xinjiang.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7403944 | PMC |
| http://dx.doi.org/10.1042/BSR20200357 | DOI Listing |
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