Successful treatment of two Japanese ESRD cases with severe COVID-19 pneumonia.

CEN Case Rep

Department of Nephrology, Japanese Red Cross Medical Center, 4-1-22 Hiro-o, Shibuya-Ku, Tokyo, 150-8935, Japan.

Published: February 2021

Novel coronavirus disease 2019 (COVID-19) is a highly infectious and deadly disease, spreading worldwide. There are limited data about the clinical course of end-stage renal disease (ESRD) patients infected with COVID-19. However, previous cohort studies showed a high mortality rate of ESRD patients infected with COVID-19. We report here two Japanese ESRD patients confirmed with severe COVID-19 pneumonia. Case 1 was a 60-year-old man with ESRD due to diabetic nephropathy who were infected with COVID-19 and exhibited acute respiratory distress syndrome (ARDS) requiring mechanical ventilation and intensive care unit (ICU) admission. He was treated with tocilizumab and intravenous immunoglobulin (IVIG). After 6 days of treatment in ICU, he was extubated. Case 2 was a 68-year-old woman undergoing maintenance hemodialysis for 17 years who also exhibited ARDS due to COVID-19. Her clinical course resembles case 1. Our experience of these two cases indicates that anti-cytokine therapy might be effective for severe COVID-19 pneumonia in ESRD patients.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7382919PMC
http://dx.doi.org/10.1007/s13730-020-00512-7DOI Listing

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