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Synthesizing and assessing influenza vaccine evidence: Strengths and limitations of the recent ECDC report on the effectiveness of new and enhanced influenza vaccines. Communication on: the "European Centre for Disease Prevention and Control. Systematic review update on the efficacy, effectiveness and safety of newer and enhanced seasonal influenza vaccines for the prevention of laboratory confirmed influenza in individuals aged 18 years and over. Stockholm: ECDC; 2024".
Germs
September 2024
MD, FESPCH, Prof., General Practitioner, Röntgenstr. 2 82152 Martinsried, Germany.
High quality research is critical for evidence-based decision making in public health and fundamental to maintain progress and trust in immunization programs in Europe. In 2024 the European Centre for Disease Prevention and Control (ECDC) conducted an update of the 2020 systematic review to capture more recent evidence on of the efficacy, effectiveness of influenza vaccines in individuals aged 18 years and older in the prevention of laboratory-confirmed influenza. While this report was highly anticipated due to the strength of the protocol and processes put in place, during our assessment, we expressed two chief concerns.
View Article and Find Full Text PDFMini-cutting condition on the identification of rooting-biomarkers in easy- and a hard-to-root Ilex paraguariensis clones.
Planta
January 2025
Universidade Federal do Paraná, Av. Prefeito Lothário Meissner, 623, Curitiba, PR, ZIP 80210-170, Brazil.
The mini-cutting physiological condition is vital for the rooting process. For accurate interpretation, considering all mini-cutting responses in an experiment is necessary to identify significant rooting-biomarkers. The study investigates rooting-biomarkers during vegetative propagation, focusing on Ilex paraguariensis (yerba mate) clones of contrasting mini-cutting rooting performance as a case study (i.
View Article and Find Full Text PDFSelective outcome reporting concerning antibiotics and third molar surgery.
Clin Oral Investig
January 2025
Department of Oral and Maxillofacial Surgery, School of Dentistry, University of São Paulo, Av. Prof. Lineu Prestes, 2227 - Cidade Universitária, São Paulo, 05508-000, Brazil.
Objectives: This study evaluates the selective outcome reporting (SOR) in clinical trials on antibiotic use in third molar surgeries. It explores how SOR may bias results and affect systematic reviews, potentially leading to misinterpretations of intervention efficacy.
Materials And Methods: A search was conducted on "ClinicalTrials.
Effect of Hemolysis on Routine Blood Gas and Whole Blood Analytes.
J Appl Lab Med
December 2024
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Background: Hemolysis is a major pre-analytical concern for many laboratory analytes; however, instruments utilized for whole blood chemistries and blood gas measurements lack the ability to detect and measure the degree of hemolysis. This study evaluated the effect of hemolysis on 13 routine whole blood and blood gas analytes and compared visual assessments of hemolysis to measured hemolysis (H-index).
Methods: Remnant whole blood samples (n = 85) were split into 2 portions and aspirated through a syringe one or more times.
Enhancing interpretability and accuracy of AI models in healthcare: a comprehensive review on challenges and future directions.
Front Robot AI
November 2024
Department of Computer Sciences and Mathematics, University of Québec at Chicoutimi, Chicoutimi, QC, Canada.
Artificial Intelligence (AI) has demonstrated exceptional performance in automating critical healthcare tasks, such as diagnostic imaging analysis and predictive modeling, often surpassing human capabilities. The integration of AI in healthcare promises substantial improvements in patient outcomes, including faster diagnosis and personalized treatment plans. However, AI models frequently lack interpretability, leading to significant challenges concerning their performance and generalizability across diverse patient populations.
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