Two new spirotetronate natural products, lobophorin L () and lobophorin M (), together with three known lobophorin-like spirotetronate antibiotics (-) and two known ansamycins (-), were isolated from the marine-derived sp. 4506. The structures of and were established on the basis of HRESIMS as well as 1D and 2D NMR datasets. Antibacterial assay showed that, compounds and - exhibited strong to moderate antibacterial activities against and with MIC values ranging from 0.0625 to 8 μg/mL, while compounds and showed weak antibacterial activities against and MRSA. The antibacterial activities of the lobophorins in this study indicated that the more substitution number of the sugar moieties at C-9 of the lobophorin, the stronger antimicrobial properties it may deserve, and the higher the oxidation degree of substituent group at C-3, the better antibacterial activities of its corresponding compound could be.
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