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The cellular characteristics of the opportunistic fungal pathogen Cryptococcus species were investigated in the infected liver of an immunocompetent host using transmission electron microscopy (TEM). With no records of immunodeficiency, the 3-year-old female patient displayed a high-grade fever, lethargy, and increasing jaundice. TEM analysis revealed the presence of round yeast cells in the patient's liver.

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Cryptococcal meningoencephalitis in a patient on immunomodulatory drug: A case report.

J Mycol Med

December 2024

Fimlab Laboratories, 33520 Tampere, Finland / Faculty of Medicine and Health Technology, Tampere University, 33014 Tampere, Finland; Northern Finland Laboratory Centre (NordLab), 90220 Oulu / Finland and Research Unit of Biomedicine, University of Oulu, 90570 Oulu, Finland.

Background: Cryptococcus neoformans is an important fungal pathogen causing pneumonia and central nervous system infections mainly in immunocompromised hosts. Fingolimod is an immunomodulatory drug approved in the US and Europe for the treatment of multiple sclerosis.

Case Presentation: We herein report a case of cryptococcal meningoencephalitis in a 46-year-old male with a history of fingolimod for five years.

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Fungal infection in patients treated with Bruton's Tyrosine Kinase inhibitor, from epidemiology to clinical outcome: A systematic review.

Clin Microbiol Infect

December 2024

Sorbonne Université, CIMI-Paris, AP-HP, Service de Parasitologie-Mycologie, Hopital de La Pitie-Salpetriere, F-75013 Paris, France. Electronic address:

Background: Bruton Tyrosine Kinase inhibitor (BTKi) emerged as key treatment for B-cell lymphomas. Despite its efficacy in the treatment of malignancies, numerous cases of invasive fungal infections (IFI) have been reported in patients receiving ibrutinib, a first generation BTKi. Cases of invasive aspergillosis have also been reported with acalabrutinib and zanubrutinib.

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Cryptococcus neoformans/gattii and Histoplasma capsulatum var. capsulatum may present atypical histopathological features inducing diagnostic errors. We aimed to estimate the frequency of these atypical features on formalin-fixed tissue samples (FT) and to assess the relevance of an integrated histomolecular diagnosis using specific Histoplasma capsulatum PCR and panfungal PCR followed by Sanger sequencing and/or targeted-massive parallel sequencing (MPS).

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