The accidental ingestion of a press-through package (PTP) sheet is associated with the risk of gastrointestinal injury and puncture. When pain occurs in the laryngeal pharynx, the PTP may already be stuck in the upper esophageal region, and urgent endoscopic treatment is necessary. A plain chest X-ray image should be performed first to identify the ingested PTP, but this was not successful in the present two patients. As a next step, a CT scan (which involves high radiation exposure) is commonly used. In our patients (a 76-year-old woman and a 59-year-old man), tomosynthesis was used to confirm the presence and location of a PTP sheet as a pre-endoscopic diagnosis. With tomosynthesis, the level of radiation exposure was reduced to approx. 1/10 of that of simple CT; the imaging time is also shorter at ~ 5 s. Tomosynthesis can be performed at approx. 1/3-1/4 the cost of simple CT. The usefulness of tomosynthesis as a pre-endoscopic diagnostic tool was demonstrated in our patients, and its further utilization is expected.
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http://dx.doi.org/10.1007/s12328-020-01185-6 | DOI Listing |
Med Devices (Auckl)
November 2024
Department of Clinical Pharmacy, Shonan University of Medical Science, Yokohama, Japan.
Purpose: Press-through packages (PTPs) are frequently used for the packaging of prescription drugs in Japan. However, tablets or capsules packaged in PTPs may become unstable and difficult to store. Therefore, aluminum pouches (pillow packages) are applied as an additional packaging option.
View Article and Find Full Text PDFJ Pharm Health Care Sci
July 2024
Division of Clinical Pharmaceutics, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-Ku, Sendai, Miyagi, 981-8558, Japan.
Background: Dispensed drugs stored by patients are often in single-dose packages (SDPs) or are crushed and mixed after being removed from a press-through package (PTP) sheet. Information on their stability is extremely limited. To address this, we explored using chemiluminescence (CL) measurements to detect oxidative degradation.
View Article and Find Full Text PDFPhys Chem Chem Phys
September 2023
Department of Thoracic Oncology, Affiliated Cancer Hospital, Guizhou Medical University, Guiyang, China.
As a ubiquitous protein tyrosine phosphatase, SHP2 is involved in PD-1/PD-L1 mediated tumor immune escape and undergoes substantial conformational changes. Therefore, it is considered an ideal target for tumor intervention. However, the allosteric mechanisms of SHP2 binding PD-1 intracellular ITIM/ITSM phosphopeptides remain unclear, which greatly hinders the development of novel structure-based anticancer allosteric inhibitors.
View Article and Find Full Text PDFSci Total Environ
October 2023
Faculty of Biological and Environmental Sciences, Ecosystems and Environment Research Programme, Lammi Biological Station, University of Helsinki, Lammi FI-16900, Finland.
Approximately one-third of the year, Daihai Lake experiences freezing conditions. During this period, the primary mechanisms that impact the quality of the lake water quality include the freezing of nutrients by the ice sheet and the migration of nutrients between the ice, water, and sediment. The present investigation involved the collection of samples of ice, water, and sediment, followed by the utilization of the thin film gradient diffusion (DGT) technique to and explore the distribution and migration of diverse nitrogen (N) and phosphorus (P) forms at the interface of ice, water and sediment.
View Article and Find Full Text PDFAccidental swallowing of press-through package (PTP) sheets that could cause esophageal perforation is commonly encountered in emergency departments requiring early detection and removal. We report a case in which an accidentally swallowed PTP sheet was removed from the esophagus using a detachable snare after usual endoscopic methods proved ineffective. A Japanese woman in her 60s visited the emergency department with a persistent sore throat.
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