AI Article Synopsis
- Tourette syndrome (TS) is a neuropsychiatric disorder where some patients experience severe and persistent tics, leading to consideration of deep brain stimulation (DBS) for symptom relief.
- A study analyzed data from the Tourette Association of America's registry, revealing that only 5.6% of patients had their DBS hardware removed, with the average age of removal being 33.8 years.
- The main reason for DBS removal was infection (46.7%), and the study found no significant links between explantation rates and common psychiatric comorbidities like OCD, depression, anxiety, or ADHD.
Article Abstract
Introduction: Tourette syndrome (TS) is a complex neuropsychiatric disorder. A small percentage of individuals with TS can experience persistent severe, refractory, and impairing tics. Deep brain stimulation (DBS) has been increasingly used for symptom management, especially in these settings. In this article, we aim to evaluate the rate and the reasons for removal of DBS hardware in TS patients.
Methods: Data was analyzed from patients enrolled in the Tourette Association of America's International Tourette Syndrome Registry and Database.
Results: Fifteen of 269 (5.6%) patients required removal of their DBS systems. The mean age at explantation was 33.8 years. In these cases we observed a rate of 1.9 explantations per year of follow up from implantation. None of the removals took place in the immediate post-operative period. Infection was the most common cause (46.7%). Only one patient received explantation for tic resolution. There were no significant associations between explantation and the presence of specific psychiatric comorbidities, including OCD, depression, anxiety, or ADHD.
Discussion: The rate of removal of 5.6% was lower than the previously reported rate in the TS DBS literature. Infections accounted for nearly half of the TS DBS explantations in this cohort. There was no relationship to psychiatric comorbidities.
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| http://dx.doi.org/10.1016/j.parkreldis.2020.06.025 | DOI Listing |
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