AI Article Synopsis
- - The study investigates the expression patterns of miR-140 and miR-196a in breast cancer (BC) patients and their potential significance in diagnosis and prognosis.
- - Results showed that miR-140 was significantly decreased, while miR-196a was increased in BC tissues compared to adjacent non-tumor tissues, with a notable relationship to lymph node metastasis and cancer stage.
- - The findings suggest that miR-140 and miR-196a could serve as potential biomarkers for breast cancer, highlighting their clinical relevance in assessing disease progression.
Article Abstract
Objective: MiR-140 and miR-196a were known to be correlated with cancer diagnosis and prognosis. The current study aimed at the analysis of miR-140 and miR-196a expression patterns and their clinical significance for breast cancer (BC) patients.
Methods: Differentially expressed miR-140 and miR-196a were examined via quantitative PCR in 110 cases of BC and their adjacent non-tumor (ANT) tissues.
Results: The results indicated that miR-140 and miR-196a, respectively, notably decreased and increased expression in BC samples in comparison with ANT (p<0.001). Reduced miR-140 expression was also related to Lymph node metastasis (LNM, P= 0.023) and stage (P = 0.009). Additionally, Receiver Operating Characteristics (ROC) analysis illustrated that miR-140 had a significant diagnostic accuracy for stage and LNM of BC patients. We also discovered a strong negative correlation between miR-196a expression with histological grade (P = 0.038), LNM (P = 0.012) and stage (P = 0.001).
Conclusion: Overall, exploring the miR-140 and miR-196a profiles not only can statistically different among BC and ANT samples, but it is also expected to become potential BC biomarkers.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7573432 | PMC |
| http://dx.doi.org/10.31557/APJCP.2020.21.7.1913 | DOI Listing |
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