Concerns have been expressed over standards of statistical interpretation. Results with P <0.05 are often referred to as 'significant' which, in plain English, implies important. This leads some people directly into the misconception that this provides proof that associations are clinically relevant. There are calls for statistics educators to respond to these concerns. This article provides novel plain English interpretations that are designed to deepen understanding. Experience teaching postgraduates at Imperial College is discussed. A key issue with focusing on 'significance' is the common inappropriate practice of implying no association exists, simply because P >0.05. Referring to strengths of association in 'study participants' gives them gravitas, which may help to avoid this. This contrasts with the common practice of focusing on imprecision, by referring to the 'sample' and to 'point estimates'. Unlike formal statistical definitions, interpretations developed and presented here are rooted in the application of statistics. They are based on one set of study participants (not many random samples). Precision of strengths of association are based on using strengths in study participants to estimate strengths of association in the population (from which participants were selected by probability random sampling). Reference to 'compatibility with study data, dependent on statistical modelling assumptions' reminds us of the importance of data quality and modelling assumptions. A straightforward graph shows the relationship between P-values and test statistics. This figure and associated interpretations were developed to illuminate the continuous nature of P-values. This is designed to discourage focus on whether P <0.05, and encourage interpretation of exact P-values.

Download full-text PDF

Source
http://dx.doi.org/10.1093/ije/dyaa080DOI Listing

Publication Analysis

Top Keywords

strengths association
12
interpretations developed
8
study participants
8
reflection modern
4
modern methods
4
statistics
4
methods statistics
4
statistics education
4
education 'significance'
4
'significance' novel
4

Similar Publications

[Not Available].

Tunis Med

January 2025

Department of Rheumatology, Kassab Institute of Orthopaedics, Mannouba. Faculty of Medicine of Tunis, University of Tunis El Manar, Tunisia.

Unlabelled: Advancements in understanding SpA have greatly improved patient quality of life through early detection and effective treatment. However, non-specialist physicians often face challenges in identifying the early symptoms of SpA.

Aim: This study aims to assist healthcare practitioners in the early detection of SpA and to streamline management strategies by employing a standardized assessment protocol for adult patients with SpA.

View Article and Find Full Text PDF

Objective: To examine rates of postpartum hemorrhagic (PPH) morbidity among patients who did and did not have immediate skin-to-skin contact (SSC).

Methods: This study was a retrospective cohort of all non-anomalous, term singleton vaginal births at a Level IV center over 2 years. Exclusion criteria included COVID-19.

View Article and Find Full Text PDF

Background: Brain-derived neurotrophic factor (BDNF) may help middle-aged and older adults resist age-related neurodegenerative conditions and psychiatric disorders. Recent studies suggested that Traditional Chinese exercises (TCEs) may be a promising strategy to improve the BDNF levels of these populations, while the effectiveness has yet to be definitively confirmed due to the variances in the study designs and observations. Therefore, this systematic review and meta-analysis aimed to examine the effects of TCEs intervention on BDNF in middle-aged and older adults.

View Article and Find Full Text PDF

ISCAZIM: Integrated statistical correlation analysis for zero-inflated microbiome data.

Heliyon

January 2025

Department of Biostatistics, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, 250012, China.

Microbiome-metabolome association analysis is critical to reveal the key pairs of gut microbiota and metabolites for discovery of the microbial biomarkers in chronic diseases. However, the characteristics of microbiome data, such as zero inflation, over dispersion, may impair the confidence of association analysis between microbiome and metabolome data. The objectives of this study are to evaluate the strengths and weaknesses of existing statistical methods and to develop a computational framework tailored to the unique characteristics of microbiome data.

View Article and Find Full Text PDF

Cellulose nanocrystals (CNCs) are a class of materials that have received significant attention in recent years due to their unique properties and potential applications. CNCs are extracted from plant fibers and possess high strength, stiffness, and biocompatibility, making them attractive materials for use in various fields such as biomedical engineering, renewable energy, and nanotechnology. This provides an in-depth discussion of the extraction, characterization, and promising applications of CNCs.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!