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Corrigendum to "WCN24-2499 CAVEOLIN-1 AND CAVEOLIN-2 AS POTENTIAL URINARY EARLY BIOMARKERS OF RENAL INJURY IN ACUTE CHOLESTASIS IN RATS" [ Volume 9, Issue 4, Supplement, April 2024, Page S541].
Kidney Int Rep
August 2024
Ciencias Fisiológicas, Faculty of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina. Institute of Experimental Physiology of Rosario (IFISE-CONICET-UNR), Rosario, Argentina, Rosario.
[This corrects the article DOI: 10.1016/j.ekir.
View Article and Find Full Text PDFBlood-brain barrier lesion - a novel determinant of autonomic imbalance in heart failure and the effects of exercise training.
Clin Sci (Lond)
August 2023
Department of Physiology and Biophysics, Biomedical Sciences Institute, University of Sao Paulo, Sao Paulo, SP, Brazil.
Heart failure (HF) is characterized by reduced ventricular function, compensatory activation of neurohormonal mechanisms and marked autonomic imbalance. Exercise training (T) is effective to reduce neurohormonal activation but the mechanism underlying the autonomic dysfunction remains elusive. Knowing that blood-brain barrier (BBB) lesion contributes to autonomic imbalance, we sought now to investigate its involvement in HF- and exercise-induced changes of autonomic control.
View Article and Find Full Text PDFHypertension depresses but exercise training restores both Mfsd2a expression and blood-brain barrier function within PVN capillaries.
Am J Physiol Regul Integr Comp Physiol
September 2023
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, São Paulo, Brazil.
Hypertension augments while exercise training corrects the increased vesicle trafficking (transcytosis) across the blood-brain barrier (BBB) within preautonomic areas and the autonomic imbalance. There is no information on a possible mechanism(s) conditioning these effects. Knowing that Mfsd2a is the major transporter of docosahexaenoic acid (DHA) and that Mfsd2a knockout mice exhibited leaky BBB, we sought to identify its possible involvement in hypertension- and exercise-induced transcytosis across the BBB.
View Article and Find Full Text PDFInhibition of cholesterol transport impairs Cav-1 trafficking and small extracellular vesicles secretion, promoting amphisome formation in melanoma cells.
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February 2023
Center for Gender-Specific Medicine, Istituto Superiore di Sanità, Rome, Italy.
Caveolin-1 (Cav-1) is a fundamental constituent of caveolae, whose functionality and structure are strictly dependent on cholesterol. In this work the U18666A inhibitor was used to study the role of cholesterol transport in the endosomal degradative-secretory system in a metastatic human melanoma cell line (WM266-4). We found that U18666A induces a shift of Cav-1 from the plasma membrane to the endolysosomal compartment, which is involved, through Multi Vesicular Bodies (MVBs), in the formation and release of small extracellular vesicles (sEVs).
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