Creating Space for Synaptic Formation-A New Role for Microglia in Synaptic Plasticity.

Cell

Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address:

Published: July 2020

Memory formation is thought to occur in the brain through dynamic remodeling of the synaptic architecture between neurons. The cellular mechanisms underlying these dynamics remain unclear. In this issue, Nguyen et al. demonstrate a novel role for microglia in regulating synaptic formation by clearing extracellular matrix proteins that embed neurons.

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http://dx.doi.org/10.1016/j.cell.2020.06.042DOI Listing

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