Targeting adhesion to the vascular niche to improve therapy for acute myeloid leukemia.

Nat Commun

Department of Life Sciences, Imperial College London, Sir Alexander Fleming Building, SW7 2AZ, London, UK.

Published: July 2020

Niche hijack by malignant cells is considered to be a prominent cause of disease relapse. Barbier and colleagues uncover (E)-selectin as a novel mediator of malignant cell survival and regeneration which, upon blockade, has the potential to significantly improve therapeutic outcomes.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378234PMC
http://dx.doi.org/10.1038/s41467-020-17594-7DOI Listing

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