Bungsteroid A: One Unusual C Pentacyclic Steroid Analogue from Maxim.

Bungsteroid A (), possessing an unreported carbon skeleton, was isolated from the pericarps of Maxim. It represents the first carbon skeleton of a C steroid analogue featuring a unique 6/6/6/6/5-fused pentacyclic skeleton, which has been determined by spectroscopic methods, quantum-chemical C NMR, ECD calculations, and calculations of optical rotations. Bungsteroid A showed the antiproliferative effects against HepG2, MCF-7, and HeLa cell lines with the IC values of 56.3 ± 1.1, 64.2 ± 0.9, and 74.2 ± 1.3 μM, respectively.