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Exploring the impact of RPN1 on tumorigenesis and immune response in cancer.
FASEB J
March 2025
Department of Oncology, The Central Hospital of Yongzhou, Yongzhou, Hunan, China.
The ribophorin family, including RPN1, has been associated with tumor progression, but its specific role in pan-cancer dynamics remains unclear. Using data from TCGA, GTEx, and Ualcan databases, we investigated the relationship of RPN1 with prognosis, genomic alterations, and epigenetic modifications across various cancers. Differential analysis revealed elevated RPN1 expression in multiple cancer types, indicating a potential prognostic value.
View Article and Find Full Text PDFPrimary Angiitis of the Central Nervous System and Its Mimics: A Pattern-Based Approach to Biopsies for Central Nervous System Vasculitis.
Arch Pathol Lab Med
March 2025
From the Department of Pathology, University of Michigan, Ann Arbor.
Context.—: Primary angiitis of the central nervous system is a rare vasculitis that affects small parenchymal and leptomeningeal vessels in the brain and spinal cord. As brain biopsy remains the gold standard in diagnosis, the diagnostic approach to brain biopsies for vasculitis is well described.
View Article and Find Full Text PDFPerinatal testicular torsion diagnosed as an intraperitoneal mass: case report and literature review.
Front Pediatr
February 2025
Department of Urology, Children's Hospital, Capital Institute of Pediatrics, Beijing, China.
Perinatal testicular torsion is not common in clinic. We report our experience in treating such a condition in a 50-day boy with an intraperitoneal mass. The clinical manifestations, physical examination, imaging examination and treatment of the boy were retrospectively analyzed and the related literatures were reviewed.
View Article and Find Full Text PDFIdentification and Experimental Validation of Biomarkers Related to MiR-125a-5p in Chronic Obstructive Pulmonary Disease.
Int J Chron Obstruct Pulmon Dis
March 2025
Department of General Medical, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, Shanxi, People's Republic of China.
Purpose: The miR-125a-5p has been reported influence the development of lung cancer, however, the link between it and chronic obstructive pulmonary disease (COPD) is still not well understood. Hence, this study was designed to investigate the molecular pathway by which miR-125a-5p related biomarkers were involved in COPD.
Patients And Methods: The differentially expressed genes (DEGs) and module genes related to COPD in GSE100153 were screened out by differential analysis and weighted gene co-expression network analysis, respectively.
Early-Onset Colorectal Cancer: When to Include Cowden Syndrome in Your Differential Diagnosis.
ACG Case Rep J
March 2025
Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.
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