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Understanding the Intricate Pathophysiology of Psoriasis and Related Skin Disorders.
Int J Mol Sci
January 2025
Department of Dermatology, Faculty of Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
Psoriasis is a chronic inflammatory condition that is polygenic and multisystemic, impacting approximately 2-3% of the global population. The onset of this disease is influenced by an intricate interplay of genetic and environmental factors, predisposing individuals to the psoriasis phenotype. The complex pathogenesis of psoriasis contains certain key aspects found in other autoinflammatory and autoimmune dermatological diseases.
View Article and Find Full Text PDFInfections in Idiopathic Inflammatory Myopathies: Do Asians Need a Different Dose of Immunosuppression?
Int J Rheum Dis
January 2025
Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK.
Recalcitrant Dermatomyositis Treated With Anifrolumab.
ACR Open Rheumatol
January 2025
Saint Louis University School of Medicine, St. Louis, Missouri.
Dermatomyositis is an idiopathic inflammatory myopathy which can present with distinctive skin features. Despite the many treatment modalities for the treatment of dermatomyositis some patients remain refractory to treatment. We present a case of a 38-year-old man with recalcitrant dermatomyositis who was successfully treated with the interferon α receptor 1-inhibiting monoclonal antibody anifrolumab.
View Article and Find Full Text PDFCase Series: The Challenge of Using Immune Checkpoint Inhibitors in Anti-Transcriptional Intermediary Factor 1 Antibody-Positive Dermatomyositis.
Int J Rheum Dis
January 2025
Department of Medicine, McGill University, Montreal, Canada.
A nomogram for the prediction of co-infection in MDA5 dermatomyositis: A rapid clinical assessment model.
Clin Immunol
January 2025
Department of Rheumatology and Immunology, Laboratory of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China. Electronic address:
Background: Patients with anti-melanoma differentiation-associated gene 5-positive dermatomyositis (MDA5 DM) are prone to infections, but there is a lack of rapid methods to assess infection risk, which greatly affects patient prognosis. This study aims to analyze the clinical features of MDA5 DM patients systematically and develop a predictive model for infections.
Methods: Retrospective analysis was performed on clinical data from 118 hospitalized patients with MDA5 DM.
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