The first measurement at the LHC of charge-dependent directed flow (v_{1}) relative to the spectator plane is presented for Pb-Pb collisions at sqrt[s_{NN}]=5.02 TeV. Results are reported for charged hadrons and D^{0} mesons for the transverse momentum intervals p_{T}>0.2 GeV/c and 3
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http://dx.doi.org/10.1103/PhysRevLett.125.022301 DOI Listing Publication Analysis
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Anal Chem
August 2024
Department of Mechanical Engineering, Clemson University, Clemson, South Carolina 29634, United States.
Surface charge is an important property of particles. It has been utilized to separate particles in microfluidic devices, where dielectrophoresis (DEP) is often the driving force. However, current DEP-based particle separations based on the charge differences work only for particles of similar sizes.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
June 2024
Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, TX 75080.
The renal elimination pathway is increasingly harnessed to reduce nonspecific accumulation of engineered nanoparticles within the body and expedite their clinical applications. While the size of nanoparticles is recognized as crucial for their passive filtration through the glomerulus due to its limited pore size, the influence of nanoparticle charge on their transport and interactions within the kidneys remains largely elusive. Herein, we report that the proximal tubule and peritubular capillary, rather than the glomerulus, serve as primary charge barriers to the transport of charged nanoparticles within the kidney.
View Article and Find Full Text PDFNeurotherapeutics
January 2024
Department of Neurosurgery, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Feinstein Institutes for Medical Research, Manhasset, NY, USA. Electronic address:
Essential tremor DBS targeting the ventral intermediate nucleus (Vim) of the thalamus and its input, the dentato-rubro-thalamic tract (DRTt), has proven to be an effective treatment strategy. We examined thalamo-cortical evoked potentials (TCEPs) and cortical dynamics during stimulation of the DRTt. We recorded TCEPs in primary motor cortex during clinical and supra-clinical stimulation of the DRTt in ten essential tremor patients.
View Article and Find Full Text PDFbioRxiv
December 2023
Cell Cycle and Cancer Biology program, Oklahoma Medical Research Foundation, 825 NE 13 St, Oklahoma City, OK 73104.
ESCO1 is an acetyltransferase enzyme that regulates chromosome organization and gene expression. It does this by modifying the Smc3 subunit of the Cohesin complex. Although ESCO1 is enriched at the base of chromatin loops in a Cohesin-dependent manner, precisely how it interacts with chromatin is unknown.
View Article and Find Full Text PDFNanomaterials (Basel)
September 2022
Department of Dentistry-Regenerative Biomaterials, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Philips van Leydenlaan 25, 6525 EX Nijmegen, The Netherlands.
Messenger RNA (mRNA) is increasingly gaining interest as a modality in vaccination and protein replacement therapy. In regenerative medicine, the mRNA-mediated expression of growth factors has shown promising results. In contrast to protein delivery, successful mRNA delivery requires a vector to induce cellular uptake and subsequent endosomal escape to reach its end destination, the ribosome.
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