Background And Objective: Meningitis is a medical and public health problem in Morocco, particularly in the North West region. The purpose of present study was to identify the pathogen in pyogenic meningitis and to determine its antibiotic susceptibility pattern Materials and Methods: A total of 247 cases were included in the diagnosis of meningitis on the basis of clinical findings and positive cerebrospinal fluid (CSF).
Results: The study included 247 cases with a mean cumulative incidence of 4.53 (100,000 Hts) meningitis in all forms during the study period. The sex ratio M/F was 1.71. Maximum numbers of cases were<15 year of age, 139 (56.3%). Bacterial meningeal syndrome was observed in 67.2% of cases. Cerebrospinal fluid (CSF) was cloudy in 57.1% of cases. The average number of GBs was 1074.12 (±2115.63) elements mm-3. Mean glycorrhachia was 0.48 g L-1 (±0.28) and mean protein levels were 1.5 g L-1 (±1.68). The common pathogens identified on CSF culture were coagulase, negative Neisseria meningitidis in 30 (13%) and Streptococcus pneumoniae 6 (2.5%). Overall mortality was 14.9%.
Conclusion: Hence, Meningitis is a real health problem in the province of Kenitra, affecting especially children. Effective involvement of all health personnel and the community fight this epidemic disease.
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http://dx.doi.org/10.3923/pjbs.2020.891.897 | DOI Listing |
J Cardiothorac Surg
January 2025
Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 167, Beilishi Road, Xicheng District, China.
Background: Heparin, an anticoagulant used in cardiac surgery, can result in heparin rebound (HR), where it returns postoperatively despite being neutralized with protamine. This study was designed to investigate the prevalence of HR in patients undergoing off-pump coronary artery bypass grafting (OPCAB) and evaluate the impact of HR on their short-term outcomes.
Methods: HR was defined by a 10% increase in activated coagulation time (ACT) following two hours of heparin neutralization with protamine, bleeding over 200 mL/h, and abnormal laboratory coagulation examination results.
Otolaryngol Clin North Am
January 2025
Department of Otolaryngology-Head and Neck Surgery, Division of Facial Plastic and Reconstructive Surgery, Henry Ford Hospital, 2799 West Grand Boulevard K-8, Detroit, MI 48202, USA; Department of Surgery, Michigan State University, 4660 South Hagadorn Road, Suite #620, East Lansing, MI 48823, USA; Wayne State University School of Medicine, 540 East Canfield Street, Detroit, MI 48201, USA.
The external nasal valve is the anatomic structure formed by the caudal septum, alar rim, medial crura of the lower lateral cartilage, and nasal sill at the level of the nasal vestibule. Evaluation of external nasal valve dysfunction is dependent upon a thorough history and physical examination. Symptoms and quality of life impact are the main drivers for patients to seek out clinical evaluation.
View Article and Find Full Text PDFTalanta
December 2024
NanoBiosensors and Biodevices Lab, School of Medical Science and Technology, Indian Institute of Technology Kharagpur, West Bengal, 721302, India. Electronic address:
This work presents a robust strategy for quantifying overlapping electrochemical signatures originating from complex mixtures and real human plasma samples using nickel-based electrochemical sensors and machine learning (ML). This strategy enables the detection of a panel of analytes without being limited by the selectivity of the transducer material and leaving accommodation of interference analysis to ML models. Here, we fabricated a non-enzymatic electrochemical sensor for L-lactic acid detection in complex mixtures and human plasma samples using nickel oxide (NiO) nanoparticle-modified glassy carbon electrodes (GCE).
View Article and Find Full Text PDFNat Genet
January 2025
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, TN, USA.
Genome-wide association studies have identified approximately 200 genetic risk loci for breast cancer, but the causal variants and target genes are mostly unknown. We sought to fine-map all known breast cancer risk loci using genome-wide association study data from 172,737 female breast cancer cases and 242,009 controls of African, Asian and European ancestry. We identified 332 independent association signals for breast cancer risk, including 131 signals not reported previously, and for 50 of them, we narrowed the credible causal variants down to a single variant.
View Article and Find Full Text PDFNat Commun
January 2025
State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Chengdu University of Technology, Chengdu, China.
The boundary between wet and arid climate zones in the Tethys Ocean remains challenging to trace, complicating our understanding of global aridification pattern during the Late Carboniferous to Early Permian transition. The North China Block (NCB), situated in the Tethys Ocean, underwent a transition from humid to arid climate during the Early Permian, providing a rare opportunity to trace this climate boundary across this region. Here, we present paleomagnetic evidence indicating that the NCB underwent rapid northward drift between 290 and 281 million years ago.
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