Itch is a frequent complaint reported by the patients and is usually ascribed to dermatological causes. Central neurogenic pruritus remains an under-recognized complication with an unclear etiology previously described in the patients with stroke or with an intramedullary mass of the spinal cord. We describe a case of a nine-year-old male who developed unilateral pruritus seven days after he underwent right hemicraniectomy due to ruptured arteriovenous malformation. The patient manifested a significant improvement in pruritus after starting gabapentin. This report highlights the need for having a high index of suspicion for central neurogenic pruritus in such patients.
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http://dx.doi.org/10.7759/cureus.8661 | DOI Listing |
Eur J Pharmacol
January 2025
Graduate Program in Pharmacology, Federal University of Santa Catarina (UFSC), 88037-000 - Florianópolis (SC), Brazil. Electronic address:
Dithranol is one of the most effective topical medications for treating plaque psoriasis. However, its clinical use is limited by irritative adverse reactions to the skin, such as oedema, erythema, and pruritus, caused by poorly understood mechanisms. Because TRPV1 activation mediates skin irritation caused by several drugs, we conducted blind and randomised experiments in male and female C57BL/6 mice to elucidate the role of TRPV1 in dithranol-induced irritation.
View Article and Find Full Text PDFBurns
February 2025
Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center, Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands; GROW school for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229 ER Maastricht, the Netherlands.
Background: Hypertrophic scars and keloids are forms of pathologic scarring that can give rise to pain and pruritus. The link between nerve function and nerve density and the symptoms in pathologic scars (PS) remains unclear.
Objective: We aim to assess current knowledge on nerve function and nerve density in PS, and to explore a possible association between alterations in sensibility/nerve density and pathologic scar symptoms.
Cutis
August 2024
Drs. Aronov and Valdman-Grinshpoun are from the Department of Dermatology and Venereology, Soroka University Medical Center, Beer-Sheva, Israel. Dr. Cohen is from the Department of Quality Measures and Research, Chief Physician's Office, Clalit Health Services, Tel Aviv, Israel. Dr. Cohen also is from and Dr. Freud is from Siaal Research Center for Family Medicine and Primary Care, The Haim Doron Division of Community Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva. Dr. Czarnowicki is from Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Israel, and the Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery, University of Miami Leonard M. Miller School of Medicine, Florida.
Fibromyalgia is a common musculoskeletal condition that affects up to 3% of the worldwide population. Its pathogenesis is not entirely clear but is thought to involve neurogenic inflammation as well as aberrations in peripheral nerves and central pain mechanisms. It is believed that the same mechanism that causes hypersensitivity and pain in patients with fibromyalgia also predisposes them to pruritus.
View Article and Find Full Text PDFJ Dermatolog Treat
December 2024
Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Purpose: Based on a potential shared pathophysiology tied to mast cell activity and neurogenic inflammation that may link pruritus and chronic cough (CC), this study, leveraging the database, examines the association between the two conditions.
Materials And Methods: A nested case-control comparison was used to examine the association, identifying cases with SNOMED codes 418363000 (pruritus) and 68154008 (CC). Matching was performed on a 1:4 ratio by age, sex, and ethnicity using the MatchIt package in R, followed by maximum likelihood method to estimate odds ratios (ORs) and 95% confidence intervals from 2x2 contingency tables.
Lasers Med Sci
February 2024
Dermatology Department, Kasr Al Ainy Faculty of Medicine, Cairo University, Cairo, Egypt.
Neurogenic inflammation, mediated by T helper 17 cell (Th17) and neurons that release neuropeptides such as substance P (SP), is thought to play a role in the pathogenesis of psoriasis. Excimer light is used in the treatment of psoriasis via induction of T cell apoptosis. The objective of this study is to study the effect of excimer light on active versus stable psoriasis and investigate the levels of substance P and its receptor in both groups.
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