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Caution: Chemical Instability of Natural Biomolecules During Routine Analysis. | LitMetric

Caution: Chemical Instability of Natural Biomolecules During Routine Analysis.

Molecules

Aix Marseille Univ, CNRS, Institut de Chimie Radicalaire UMR7273, 13397 Marseille, France.

Published: July 2020

Natural products (NPs) constitute a significant source of active biomolecules widely used in medicine, pharmacology and cosmetics. However, NPs structural characterization has the drawback of their chemical instability during the extraction steps and their likely transformation during the analytical protocol. In particular, tamariscol and conocephalenol are two compounds largely used in the cosmetic industry for their odorant properties. Thus, in the present study, we focused on the evolution of these two metabolites (extracted from and respectively), as followed by NMR. Interestingly, we found that, once dissolved in deuterated chloroform, these two tertiary alcohols are both subjected to transformation processes, leading to degradation compounds with altered structures. Accordingly, these detected degradation compounds have been fully characterized by NMR and the experimental findings were supported by computational chemistry data.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7397321PMC
http://dx.doi.org/10.3390/molecules25143292DOI Listing

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