Objective: Investigate the impact of resveratrol (RESV) on peri-implant repair and its effect on bone-related markers in rats with induced diabetes mellitus (DM).
Material And Methods: Ninety rats were divided into: DM + RESV ( = 18); DM + placebo (PLAC) ( = 18); DM + insulin (INS) ( = 18); DM + RESV + INS ( = 18); Non-DM ( = 18). Diabetes was induced by streptozotocin. One screw-shaped titanium implant was inserted in each tibiae of animals. Treatments were administered during 30 days. After, one of the implants was removed for counter-torque and the peri-implant tissue was collected for mRNA quantification of BMP-2, OPN, Runx2, Lrp-5, Osx, β-catenin, Dkk1, OPG, and RANKL by Real-time PCR. The other tibia was submitted to MicroCT analysis to measure: bone volume (BV/TV), trabecular thickness (Tb.Th) and bone-implant contact (BIC).
Results: Higher counter-torque values were observed for implant removal in DM + RESV, DM + RESV + INS and Non-DM groups when compared to DM + PLAC ( < .05). Augmented Tb.Th was observed in DM + RESV and Non-DM when compared to DM + PLAC group ( < .05), whereas higher BIC was detected in DM + RESV, DM + RESV + INS and Non-DM animals when compared to DM + PLAC ( < .05). Levels of RANKL were downregulated by the RESV and/or INS therapy, whereas only the association of RESV and INS upregulated the levels of Runx2 ( < .05).
Conclusions: The therapy with RESV may favour peri-implant bone repair improving bone formation around implants.
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